benzoic acid (1R)-[(4S)-methyl-5-(triisopropyl-silanyloxy)-pentyl]-prop-2-ynyl ester

Base Information

Chemical Name:benzoic acid (1R)-[(4S)-methyl-5-(triisopropyl-silanyloxy)-pentyl]-prop-2-ynyl ester
CAS No.:342607-31-2
Molecular Formula:C₂₅H₄₀O₃Si
Molecular Weight:416.676
Hs Code.:

Synonyms:benzoic acid (1R)-[(4S)-methyl-5-(triisopropyl-silanyloxy)-pentyl]-prop-2-ynyl ester

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Chemical Property of benzoic acid (1R)-[(4S)-methyl-5-(triisopropyl-silanyloxy)-pentyl]-prop-2-ynyl ester

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Technology Process of benzoic acid (1R)-[(4S)-methyl-5-(triisopropyl-silanyloxy)-pentyl]-prop-2-ynyl ester

There total 6 articles about benzoic acid (1R)-[(4S)-methyl-5-(triisopropyl-silanyloxy)-pentyl]-prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 342607-12-9
benzoic acid 4-hydroxy-4-methyl-(1R)-[(4S)-methyl-5-(triisopropyl-silanyloxy)-pentyl]-pent-2-ynyl ester

: 342607-31-2
benzoic acid (1R)-[(4S)-methyl-5-(triisopropyl-silanyloxy)-pentyl]-prop-2-ynyl ester

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In toluene; for 26h; Heating;
DOI:10.1021/jo015791h DOI:10.1021/ja0155635

Reference yield:

: (S)-2,9-Dimethyl-10-triisopropylsilanyloxy-dec-3-yne-2,5-diol

: 342607-31-2
benzoic acid (1R)-[(4S)-methyl-5-(triisopropyl-silanyloxy)-pentyl]-prop-2-ynyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 4.44 g / NEt₃; DMAP / CH₂Cl₂ / 1 h / 20 °C

2: 85 percent / K₂CO₃; 18-crown-6 / toluene / 26 h / Heating

With dmap; 18-crown-6 ether; potassium carbonate; triethylamine; In dichloromethane; toluene;
DOI:10.1021/ja0155635

Reference yield:

: 342607-11-8
(5S)-methyl-6-(triisopropyl-silanyloxy)-hexanal

: 342607-31-2
benzoic acid (1R)-[(4S)-methyl-5-(triisopropyl-silanyloxy)-pentyl]-prop-2-ynyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: (+)-N-methylephedrine; Zn(OTf)2; NEt₃ / toluene / 26 h / 20 °C

2: 4.44 g / NEt₃; DMAP / CH₂Cl₂ / 1 h / 20 °C

3: 85 percent / K₂CO₃; 18-crown-6 / toluene / 26 h / Heating

With dmap; 18-crown-6 ether; zinc trifluoromethanesulfonate; potassium carbonate; (+)-N-methylephedrine; triethylamine; In dichloromethane; toluene;
DOI:10.1021/ja0155635