342607-12-9

Upstream product

• 98-88-4 benzoyl chloride 
• 1028269-23-9 (5R,9S)-2,9-Dimethyl-10-triisopropylsilanyloxy-dec-3-yne-2,5-diol 
• 13154-24-0 triisopropylsilyl chloride 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 219990-11-1 (R,R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-2-(S)-dimethyl-6-hepteneamide 
• 342607-10-7 triisopropyl-((2S)-methyl-hept-6-enyloxy)-silane 
• 342607-11-8 (5S)-methyl-6-(triisopropyl-silanyloxy)-hexanal 

Downstream Products

• 152044-53-6 epithilone A 
• 342607-31-2 benzoic acid (1R)-[(4S)-methyl-5-(triisopropyl-silanyloxy)-pentyl]-prop-2-ynyl ester 

Relevant academic research and scientific papers

Stereoselective syntheses of epothilones A and B via nitrile oxide cycloadditions and related studies

The expedient and fully stereocontrolled synthesis of epothilones A and B are described. The routes described make extensive study of nitrile oxide cycloadditions as surrogates for aldol addition reactions and have led to the realization of a highly convergent synthesis based on the Kanemasa hydroxyl-directed nitrile oxide cycloaddition. As well, our synthetic efforts have led to the development of new reaction methodologies and served as the proving ground for several modern methods for asymmetric carbon-carbon bond formation.

Discovery and study of new reaction chemistry; applications in complex molecule assembly

The catalytic, in situ generation of metal alkynilides under conditions compatible with electrophilic reaction partners provides fresh avenues for the development of new efficient asymmetric processes leading to C-C bond-formation. We have documented that