N-(4-nitrocinnamoyl)-2-hydroxy-2-trifluoromethyl-(3,4-methylenedioxyphenyl)ethylamine

Base Information

Chemical Name:N-(4-nitrocinnamoyl)-2-hydroxy-2-trifluoromethyl-(3,4-methylenedioxyphenyl)ethylamine
CAS No.:286930-76-5
Molecular Formula:C₁₉H₁₅F₃N₂O₆
Molecular Weight:424.333
Hs Code.:

Synonyms:N-(4-nitrocinnamoyl)-2-hydroxy-2-trifluoromethyl-(3,4-methylenedioxyphenyl)ethylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-nitrocinnamoyl)-2-hydroxy-2-trifluoromethyl-(3,4-methylenedioxyphenyl)ethylamine

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Technology Process of N-(4-nitrocinnamoyl)-2-hydroxy-2-trifluoromethyl-(3,4-methylenedioxyphenyl)ethylamine

There total 4 articles about N-(4-nitrocinnamoyl)-2-hydroxy-2-trifluoromethyl-(3,4-methylenedioxyphenyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 792895-22-8
2-hydroxy-2-trifluoromethyl-(3,4-methylenedioxyphenyl)ethylamine

: 22440-58-0,61921-33-3
(E)-4-nitrocinnamic acid chloride

: 286930-76-5
N-(4-nitrocinnamoyl)-2-hydroxy-2-trifluoromethyl-(3,4-methylenedioxyphenyl)ethylamine

Guidance literature:: With sodium carbonate; In diethyl ether; at 20 ℃; for 2h;
DOI:10.1002/jhet.5570370219

Reference yield:

: 17680-04-5
(3,4-methylenedioxy)phenylmagnesium bromide

: 286930-76-5
N-(4-nitrocinnamoyl)-2-hydroxy-2-trifluoromethyl-(3,4-methylenedioxyphenyl)ethylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / tetrahydrofuran / 1 h / -70 °C

2: K₂CO₃ / 2 h / 20 °C

3: H₂ / Pd/C / methanol / 8 h / 20 °C / 5250.42 Torr

4: 69 percent / aq. Na₂CO₃ / diethyl ether / 2 h / 20 °C

With hydrogen; sodium carbonate; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; 1: Substitution / 2: Addition / 3: Catalytic hydrogenation / 4: Condensation;
DOI:10.1002/jhet.5570370219

Reference yield:

: 102124-73-2
α,α,α-trifluoro-3,4-methylenedioxyacetophenone

: 286930-76-5
N-(4-nitrocinnamoyl)-2-hydroxy-2-trifluoromethyl-(3,4-methylenedioxyphenyl)ethylamine

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / 2 h / 20 °C

2: H₂ / Pd/C / methanol / 8 h / 20 °C / 5250.42 Torr

3: 69 percent / aq. Na₂CO₃ / diethyl ether / 2 h / 20 °C

With hydrogen; sodium carbonate; potassium carbonate; palladium on activated charcoal; In methanol; diethyl ether; 1: Addition / 2: Catalytic hydrogenation / 3: Condensation;
DOI:10.1002/jhet.5570370219