ethyl (2E,4S,5R)-6-{[tert-butyl(dimethyl)silyl]oxy}-4-[(4-methoxyphenyl)amino]-3,5-dimethylhex-2-enoate

Base Information

Chemical Name:ethyl (2E,4S,5R)-6-{[tert-butyl(dimethyl)silyl]oxy}-4-[(4-methoxyphenyl)amino]-3,5-dimethylhex-2-enoate
CAS No.:1072091-06-5
Molecular Formula:C₂₃H₃₉NO₄Si
Molecular Weight:421.652
Hs Code.:

Synonyms:ethyl (2E,4S,5R)-6-{[tert-butyl(dimethyl)silyl]oxy}-4-[(4-methoxyphenyl)amino]-3,5-dimethylhex-2-enoate

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Chemical Property of ethyl (2E,4S,5R)-6-{[tert-butyl(dimethyl)silyl]oxy}-4-[(4-methoxyphenyl)amino]-3,5-dimethylhex-2-enoate

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Technology Process of ethyl (2E,4S,5R)-6-{[tert-butyl(dimethyl)silyl]oxy}-4-[(4-methoxyphenyl)amino]-3,5-dimethylhex-2-enoate

There total 6 articles about ethyl (2E,4S,5R)-6-{[tert-butyl(dimethyl)silyl]oxy}-4-[(4-methoxyphenyl)amino]-3,5-dimethylhex-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₄₀N₂O₄Si

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 1072091-06-5
ethyl (2E,4S,5R)-6-{[tert-butyl(dimethyl)silyl]oxy}-4-[(4-methoxyphenyl)amino]-3,5-dimethylhex-2-enoate

: ethyl (2Z,4S,5R)-6-{[tert-butyl(dimethyl)silyl]oxy}-4-[(4-methoxyphenyl)amino]-3,5-dimethylhex-2-enoate

Guidance literature:: C₂₁H₄₀N₂O₄Si; ethyl (triphenylphosphoranylidene)acetate; In toluene; for 36h; Heating / reflux;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h;

Reference yield:

: 124156-21-4
ethyl (4-methoxyphenylimino)acetate

: 1072091-06-5
ethyl (2E,4S,5R)-6-{[tert-butyl(dimethyl)silyl]oxy}-4-[(4-methoxyphenyl)amino]-3,5-dimethylhex-2-enoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: (3R,5R)-5-methyl-3-pyrrolidinecarboxylic acid / dimethyl sulfoxide / 1 h / 20 °C

2.1: sodium tetrahydroborate / methanol; dimethyl sulfoxide / 0.5 h / 0 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 10.5 h / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -10 °C

5.1: tetrahydrofuran; diethyl ether / 0.5 h / -78 °C

6.1: toluene / 36 h / Heating / reflux

6.2: 1 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; lithium hexamethyldisilazane; (3R,5R)-5-methyl-3-pyrrolidinecarboxylic acid; In tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 409095-87-0
ethyl (2S,3R)-3-formyl-2-(4-methoxyphenylamino)butanoate

: 1072091-06-5
ethyl (2E,4S,5R)-6-{[tert-butyl(dimethyl)silyl]oxy}-4-[(4-methoxyphenyl)amino]-3,5-dimethylhex-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / methanol; dimethyl sulfoxide / 0.5 h / 0 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 10.5 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -10 °C

4.1: tetrahydrofuran; diethyl ether / 0.5 h / -78 °C

5.1: toluene / 36 h / Heating / reflux

5.2: 1 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;