N-{(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}-7-hydroxyheptaneamide

Base Information

• Chemical Name: N-{(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}-7-hydroxyheptaneamide
• CAS No.: 1072091-17-8
• Molecular Formula: C₂₃H₃₄INO₃
• Molecular Weight: 499.432
• Mol file: 1072091-17-8.mol

Synonyms:N-{(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}-7-hydroxyheptaneamide

Chemical Property of N-{(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}-7-hydroxyheptaneamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}-7-hydroxyheptaneamide

There total 7 articles about N-{(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}-7-hydroxyheptaneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C29H48INO3Si (1072091-21-4) → N-{(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}-7-hydroxyheptaneamide (1072091-17-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield:

(2R,3S,4E)-6-(benzyloxy)-3-[(4-methoxyphenyl)amino]-2,4-dimethylhex-4-en-1-ol (1072091-12-3) → N-{(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}-7-hydroxyheptaneamide (1072091-17-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sulfuric acid; periodic acid / water; acetonitrile / 1.5 h / 20 °C

1.2: 8 h / 20 °C

2.1: Dess-Martin periodane / dichloromethane / 0.17 h / 20 °C

3.1: chromium dichloride / tetrahydrofuran / 5.5 h / 0 - 20 °C

4.1: dichloromethane / 3 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C

With chromium dichloride; sulfuric acid; tetrabutyl ammonium fluoride; benzotriazol-1-ol; Dess-Martin periodane; periodic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

N-[(1S,2E)-4-(benzyloxy)-1-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-2-methylbut-2-en-1-yl]-4-methoxyaniline (1072091-09-8) → N-{(1S,2E)-4-(benzyloxy)-1-[(1S,2E)-3-iodo-1-methylprop-2-en-1-yl]-2-methylbut-2-en-1-yl}-7-hydroxyheptaneamide (1072091-17-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2.1: sulfuric acid; periodic acid / water; acetonitrile / 1.5 h / 20 °C

2.2: 8 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 0.17 h / 20 °C

4.1: chromium dichloride / tetrahydrofuran / 5.5 h / 0 - 20 °C

5.1: dichloromethane / 3 h / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C

With chromium dichloride; sulfuric acid; tetrabutyl ammonium fluoride; benzotriazol-1-ol; Dess-Martin periodane; periodic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

C₂₉H₄₈INO₃Si

(2R,3S,4E)-6-(benzyloxy)-3-[(4-methoxyphenyl)amino]-2,4-dimethylhex-4-en-1-ol

ethyl (2E,4S,5R)-6-{[tert-butyl(dimethyl)silyl]oxy}-4-[(4-methoxyphenyl)amino]-3,5-dimethylhex-2-enoate

C₂₀H₂₉NO₄

Downstream raw materials:

C₂₃H₃₂INO₃

C₂₃H₃₃NO₃

(2S,3S,4E)-2-[(1E)-3-(benzyloxy)-1-methylprop-1-en-1-yl]-3-methyl-12-oxaazacyclododec-4-en-6-yl acetate