(2S,4R)-tert-butyl 4-hydroxy-2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (2S,4R)-tert-butyl 4-hydroxy-2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate
• CAS No.: 1034128-42-1
• Molecular Formula: C₁₈H₂₅NO₅
• Molecular Weight: 335.4

Synonyms:(2S,4R)-tert-butyl 4-hydroxy-2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

Chemical Property of (2S,4R)-tert-butyl 4-hydroxy-2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

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Technology Process of (2S,4R)-tert-butyl 4-hydroxy-2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

There total 1 articles about (2S,4R)-tert-butyl 4-hydroxy-2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(2S,4R)-tert-butyl 4-hydroxy-2-(2-(methoxy(methyl)amino)-2-oxoethyl)pyrrolidine-1-carboxylate (1034128-59-0) + 1-bromo-4-methoxy-benzene (104-92-7) → (2S,4R)-tert-butyl 4-hydroxy-2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate (1034128-42-1)

Guidance literature:

1-bromo-4-methoxy-benzene; With magnesium; iodine; In tetrahydrofuran; for 1h; Heating;

(2S,4R)-tert-butyl 4-hydroxy-2-(2-(methoxy(methyl)amino)-2-oxoethyl)pyrrolidine-1-carboxylate; In tetrahydrofuran; for 2h; Further stages.;

DOI:10.1016/j.bmc.2008.02.073

Reference yield: 99.0%

(2S,4R)-tert-butyl 4-hydroxy-2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate (1034128-42-1) + acetic anhydride (108-24-7) → (2S,4R)-tert-butyl 4-acetoxy-2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate (1034128-43-2)

Guidance literature:

With dmap; In pyridine; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.bmc.2008.02.073

Reference yield: 74.0%

(2S,4R)-tert-butyl 4-hydroxy-2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate (1034128-42-1) + benzyl bromide (100-39-0) → (2S,4R)-tert-butyl 4-(benzyloxy)-2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate (1034128-44-3)

Guidance literature:

With silver(l) oxide; In toluene; at 20 ℃; for 3.33333h;

DOI:10.1016/j.bmc.2008.02.073

upstream raw materials:

(2S,4R)-tert-butyl 4-hydroxy-2-(2-(methoxy(methyl)amino)-2-oxoethyl)pyrrolidine-1-carboxylate

1-bromo-4-methoxy-benzene

Downstream raw materials:

(2S,4R)-tert-butyl 4-acetoxy-2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

(2S,4R)-tert-butyl 4-(benzyloxy)-2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

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