(R)-2-((E)-3-(4-aminophenyl)acrylamido)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methylpentanamide

Base Information

Chemical Name:(R)-2-((E)-3-(4-aminophenyl)acrylamido)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methylpentanamide
CAS No.:1392506-16-9
Molecular Formula:C₃₄H₃₆ClN₅O₃
Molecular Weight:598.145
Hs Code.:

Synonyms:(R)-2-((E)-3-(4-aminophenyl)acrylamido)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methylpentanamide

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Chemical Property of (R)-2-((E)-3-(4-aminophenyl)acrylamido)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methylpentanamide

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Technology Process of (R)-2-((E)-3-(4-aminophenyl)acrylamido)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methylpentanamide

There total 3 articles about (R)-2-((E)-3-(4-aminophenyl)acrylamido)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392506-35-2
tert-butyl (4-((E)-3-(((R)-1-(((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-3-oxoprop-1-en-1-yl)phenyl)carbamate

: 1392506-16-9
(R)-2-((E)-3-(4-aminophenyl)acrylamido)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methylpentanamide

Guidance literature:: tert-butyl (4-((E)-3-(((R)-1-(((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-3-oxoprop-1-en-1-yl)phenyl)carbamate; With trifluoroacetic acid; at 20 ℃; Neat (no solvent);

With water; sodium carbonate; pH=12;
DOI:10.1016/j.ejmech.2012.05.022

Reference yield:

: 1198-40-9
4-amino-7-chloroquinoline

: 1392506-16-9
(R)-2-((E)-3-(4-aminophenyl)acrylamido)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methylpentanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

2.1: trifluoroacetic acid / 20 °C / Neat (no solvent)

2.2: pH 12

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

3.2: 24 h / 0 - 20 °C

4.1: trifluoroacetic acid / 20 °C / Neat (no solvent)

4.2: pH 12

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / Reflux

5.2: 72 h

6.1: trifluoroacetic acid / 20 °C / Neat (no solvent)

6.2: pH 12

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.05.022

Reference yield:

: 1392506-07-8
(R)-tert-butyl (1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)carbamate

: 1392506-16-9
(R)-2-((E)-3-(4-aminophenyl)acrylamido)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methylpentanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / 20 °C / Neat (no solvent)

1.2: pH 12

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

2.2: 24 h / 0 - 20 °C

3.1: trifluoroacetic acid / 20 °C / Neat (no solvent)

3.2: pH 12

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / Reflux

4.2: 72 h

5.1: trifluoroacetic acid / 20 °C / Neat (no solvent)

5.2: pH 12

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2012.05.022