(2S)-N-(9-p-bromophenylfluoren-9-yl)alanine isoxazolidine

Base Information

Chemical Name:(2S)-N-(9-p-bromophenylfluoren-9-yl)alanine isoxazolidine
CAS No.:225098-22-6
Molecular Formula:C₂₅H₂₃BrN₂O₂
Molecular Weight:463.374
Hs Code.:

Synonyms:(2S)-N-(9-p-bromophenylfluoren-9-yl)alanine isoxazolidine

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Chemical Property of (2S)-N-(9-p-bromophenylfluoren-9-yl)alanine isoxazolidine

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Technology Process of (2S)-N-(9-p-bromophenylfluoren-9-yl)alanine isoxazolidine

There total 5 articles about (2S)-N-(9-p-bromophenylfluoren-9-yl)alanine isoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 39657-45-9
isoxazolidine hydrochloride

: 225098-20-4
(2S)-N-[9-(4-bromophenyl)-9-fluorenyl]alanine

: 225098-22-6
(2S)-N-(9-p-bromophenylfluoren-9-yl)alanine isoxazolidine

Guidance literature:: With dmap; benzotriazol-1-ol; dacarbazine; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/jo982413c

Reference yield:

: 486-25-9,952573-42-1
9-fluorenone

: 225098-22-6
(2S)-N-(9-p-bromophenylfluoren-9-yl)alanine isoxazolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20-25 min, 2.) THF, -78 deg C, 5 min; -78 deg C to room temperature, 60 min

2: 92 percent / K₃PO₄, Pb(NO₃)2 / acetonitrile / 36 h / Ambient temperature

3: 97 percent / aq. LiOH / dioxane / 3 h / Heating

4: 91 percent / HOBt, Et(i-Pr)2N, DMAP, DIC / CH₂Cl₂ / 3 h / 0 °C

With dmap; lithium hydroxide; potassium phosphate; n-butyllithium; lead(II) nitrate; benzotriazol-1-ol; dacarbazine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jo982413c

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 225098-22-6
(2S)-N-(9-p-bromophenylfluoren-9-yl)alanine isoxazolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20-25 min, 2.) THF, -78 deg C, 5 min; -78 deg C to room temperature, 60 min

2: 92 percent / K₃PO₄, Pb(NO₃)2 / acetonitrile / 36 h / Ambient temperature

3: 97 percent / aq. LiOH / dioxane / 3 h / Heating

4: 91 percent / HOBt, Et(i-Pr)2N, DMAP, DIC / CH₂Cl₂ / 3 h / 0 °C

With dmap; lithium hydroxide; potassium phosphate; n-butyllithium; lead(II) nitrate; benzotriazol-1-ol; dacarbazine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jo982413c