(S)-2,6-dimethoxy-N-methyl-N-(4-(1-methyl-1H-pyrrole-2-carboxamido)-1-phenylbutan-2-yl)isonicotinamide

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Chemical Name:(S)-2,6-dimethoxy-N-methyl-N-(4-(1-methyl-1H-pyrrole-2-carboxamido)-1-phenylbutan-2-yl)isonicotinamide
CAS No.:1312559-48-0
Molecular Formula:C₂₅H₃₀N₄O₄
Molecular Weight:450.538
Hs Code.:

Synonyms:(S)-2,6-dimethoxy-N-methyl-N-(4-(1-methyl-1H-pyrrole-2-carboxamido)-1-phenylbutan-2-yl)isonicotinamide

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Chemical Property of (S)-2,6-dimethoxy-N-methyl-N-(4-(1-methyl-1H-pyrrole-2-carboxamido)-1-phenylbutan-2-yl)isonicotinamide

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Technology Process of (S)-2,6-dimethoxy-N-methyl-N-(4-(1-methyl-1H-pyrrole-2-carboxamido)-1-phenylbutan-2-yl)isonicotinamide

There total 7 articles about (S)-2,6-dimethoxy-N-methyl-N-(4-(1-methyl-1H-pyrrole-2-carboxamido)-1-phenylbutan-2-yl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 6274-82-4
2,6-dimethoxypyridine-4-carboxylic acid

: 1-methyl-1H-pyrrole-2-carboxylic acid ((S)-3-methylamino-4-phenylbutyl)amide hydrochloride

: 1312559-48-0
(S)-2,6-dimethoxy-N-methyl-N-(4-(1-methyl-1H-pyrrole-2-carboxamido)-1-phenylbutan-2-yl)isonicotinamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

: 1312559-48-0
(S)-2,6-dimethoxy-N-methyl-N-(4-(1-methyl-1H-pyrrole-2-carboxamido)-1-phenylbutan-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: N,N-dimethyl-formamide / 5 h / 60 °C

3: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 25 °C

4: hydrogen; ammonia / nickel / methanol / 30 h / 20 °C / 760.05 Torr

5: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C

6: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.5 h / 20 °C

7: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C

With hydrogenchloride; ammonia; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; nickel; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 126301-19-7,134807-64-0,109687-66-3
(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropyl methanesulfonate

: 1312559-48-0
(S)-2,6-dimethoxy-N-methyl-N-(4-(1-methyl-1H-pyrrole-2-carboxamido)-1-phenylbutan-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1: N,N-dimethyl-formamide / 5 h / 60 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 25 °C

3: hydrogen; ammonia / nickel / methanol / 30 h / 20 °C / 760.05 Torr

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C

5: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.5 h / 20 °C

6: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C

With hydrogenchloride; ammonia; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; nickel; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;