1-[4-chloro-6-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidin-5-yl]ethanol

Base Information

Chemical Name:1-[4-chloro-6-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidin-5-yl]ethanol
CAS No.:1448594-74-8
Molecular Formula:C₂₀H₁₇ClF₄N₄O₂
Molecular Weight:456.827
Hs Code.:

Synonyms:1-[4-chloro-6-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidin-5-yl]ethanol

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Chemical Property of 1-[4-chloro-6-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidin-5-yl]ethanol

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Technology Process of 1-[4-chloro-6-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidin-5-yl]ethanol

There total 4 articles about 1-[4-chloro-6-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidin-5-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1448594-73-7
2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethanamine hydrochloride

: 60025-05-0
4,6-dichloro-5-(α-hydroxyethyl)pyrimidine

: 1448594-74-8
1-[4-chloro-6-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidin-5-yl]ethanol

Guidance literature:: 2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethanamine hydrochloride; With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.0833333h;

4,6-dichloro-5-(α-hydroxyethyl)pyrimidine; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 4h;

Reference yield: 100.0%

: 1448545-46-7
2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethanamine hydrochloride

: 60025-05-0
4,6-dichloro-5-(α-hydroxyethyl)pyrimidine

: 1448594-74-8
1-[4-chloro-6-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidin-5-yl]ethanol

Guidance literature:: 2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethanamine hydrochloride; With triethylamine; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.0833333h;

4,6-dichloro-5-(α-hydroxyethyl)pyrimidine; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 4h;

Reference yield:

: 1448545-44-5
2-(2-fluoro-4-hydroxyphenyl)ethylamine-tert-butyl carbamate

: 1448594-74-8
1-[4-chloro-6-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidin-5-yl]ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 0.17 h / 20 °C

1.2: 6 h / 160 °C

1.3: 20 °C

2.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.08 h / 20 °C

2.2: 4 h / 80 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In 1-methyl-pyrrolidin-2-one;