4-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]-5-methyl-5H-furo[3,4-d]pyrimidin-7-one

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Chemical Name:4-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]-5-methyl-5H-furo[3,4-d]pyrimidin-7-one
CAS No.:1448594-63-5
Molecular Formula:C₂₁H₁₆F₄N₄O₃
Molecular Weight:448.377
Hs Code.:

Synonyms:4-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]-5-methyl-5H-furo[3,4-d]pyrimidin-7-one

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Chemical Property of 4-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]-5-methyl-5H-furo[3,4-d]pyrimidin-7-one

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Technology Process of 4-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]-5-methyl-5H-furo[3,4-d]pyrimidin-7-one

There total 4 articles about 4-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]-5-methyl-5H-furo[3,4-d]pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1448594-74-8
1-[4-chloro-6-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidin-5-yl]ethanol

: 1448594-63-5
4-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]-5-methyl-5H-furo[3,4-d]pyrimidin-7-one

Guidance literature:: With bis(acetonitrile)palladium(II) dichloride; carbon monoxide; triethylamine; In methanol; at 100 ℃; for 12h; under 3750.38 Torr; Sealed tube;

Reference yield: 27.0%

: 201230-82-2
carbon monoxide

: 1448594-74-8
1-[4-chloro-6-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]pyrimidin-5-yl]ethanol

: 1448594-63-5
4-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]-5-methyl-5H-furo[3,4-d]pyrimidin-7-one

Guidance literature:: With dichloro bis(acetonitrile) palladium(II); triethylamine; In methanol; at 100 ℃; for 12h; under 3750.38 Torr; High pressure; Sealed tube;

Reference yield:

: 1448545-44-5
2-(2-fluoro-4-hydroxyphenyl)ethylamine-tert-butyl carbamate

: 1448594-63-5
4-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethylamino]-5-methyl-5H-furo[3,4-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 0.17 h / 20 °C

1.2: 6 h / 160 °C

1.3: 20 °C

2.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.08 h / 20 °C

2.2: 4 h / 80 °C

3.1: dichloro bis(acetonitrile) palladium(II); triethylamine / methanol / 12 h / 100 °C / 3750.38 Torr / High pressure; Sealed tube

With dichloro bis(acetonitrile) palladium(II); potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; In 1-methyl-pyrrolidin-2-one; methanol;