(3aR,4S,6S,7aR)-6-Benzyloxy-1-(4-methoxy-phenyl)-4,7a-dimethyl-hexahydro-pyrano[4,3-d]oxazol-2-one

Base Information

Chemical Name:(3aR,4S,6S,7aR)-6-Benzyloxy-1-(4-methoxy-phenyl)-4,7a-dimethyl-hexahydro-pyrano[4,3-d]oxazol-2-one
CAS No.:413193-68-7
Molecular Formula:C₂₂H₂₅NO₅
Molecular Weight:383.444
Hs Code.:

Synonyms:(3aR,4S,6S,7aR)-6-Benzyloxy-1-(4-methoxy-phenyl)-4,7a-dimethyl-hexahydro-pyrano[4,3-d]oxazol-2-one

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Chemical Property of (3aR,4S,6S,7aR)-6-Benzyloxy-1-(4-methoxy-phenyl)-4,7a-dimethyl-hexahydro-pyrano[4,3-d]oxazol-2-one

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Technology Process of (3aR,4S,6S,7aR)-6-Benzyloxy-1-(4-methoxy-phenyl)-4,7a-dimethyl-hexahydro-pyrano[4,3-d]oxazol-2-one

There total 8 articles about (3aR,4S,6S,7aR)-6-Benzyloxy-1-(4-methoxy-phenyl)-4,7a-dimethyl-hexahydro-pyrano[4,3-d]oxazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 413193-14-3
(4-Methoxy-phenyl)-carbamic acid (2S,3R,6S)-6-benzyloxy-2,4-dimethyl-3,6-dihydro-2H-pyran-3-yl ester

: 413193-68-7
(3aR,4S,6S,7aR)-6-Benzyloxy-1-(4-methoxy-phenyl)-4,7a-dimethyl-hexahydro-pyrano[4,3-d]oxazol-2-one

Guidance literature:: With sodium hydrogencarbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide; at 90 ℃; for 24h;
DOI:10.1021/ja012126h

Reference yield:

: 413193-10-9
(4-Methoxy-phenyl)-carbamic acid (Z)-(R)-4-hydroxy-1-((S)-1-hydroxy-ethyl)-2-methyl-but-2-enyl ester

: 413193-68-7
(3aR,4S,6S,7aR)-6-Benzyloxy-1-(4-methoxy-phenyl)-4,7a-dimethyl-hexahydro-pyrano[4,3-d]oxazol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: IBX / tetrahydrofuran; dimethylsulfoxide / 0.5 h / 25 °C

1.2: 90 percent / CSA / CH₂Cl₂ / 2 h / 25 °C

2.1: 71 percent / o-iodoxybenzoic acid; NaHCO₃ / tetrahydrofuran; dimethylsulfoxide / 24 h / 90 °C

With sodium hydrogencarbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/ja012126h

Reference yield:

: 413193-02-9
2-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-hex-4-en-3-ol

: 413193-68-7
(3aR,4S,6S,7aR)-6-Benzyloxy-1-(4-methoxy-phenyl)-4,7a-dimethyl-hexahydro-pyrano[4,3-d]oxazol-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 79 percent / DBU / CH₂Cl₂ / 10 h / 25 °C

2.1: 80 percent / TBAF / tetrahydrofuran / 1 h / 25 °C

3.1: IBX / tetrahydrofuran; dimethylsulfoxide / 0.5 h / 25 °C

3.2: 90 percent / CSA / CH₂Cl₂ / 2 h / 25 °C

4.1: 71 percent / o-iodoxybenzoic acid; NaHCO₃ / tetrahydrofuran; dimethylsulfoxide / 24 h / 90 °C

With tetrabutyl ammonium fluoride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ja012126h