5-[2-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-cyclopropylmethanesulfonyl]-1-phenyl-1H-tetrazole

Base Information

Chemical Name:5-[2-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-cyclopropylmethanesulfonyl]-1-phenyl-1H-tetrazole
CAS No.:1026355-03-2
Molecular Formula:C₂₉H₃₄N₄O₃SSi
Molecular Weight:546.765
Hs Code.:

5-[2-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-3-methyl-cyclopropylmethanesulfonyl]-1-phenyl-1<i>H</i>-tetrazole

Synonyms:5-[2-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-cyclopropylmethanesulfonyl]-1-phenyl-1H-tetrazole

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Chemical Property of 5-[2-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-cyclopropylmethanesulfonyl]-1-phenyl-1H-tetrazole

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Technology Process of 5-[2-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-cyclopropylmethanesulfonyl]-1-phenyl-1H-tetrazole

There total 4 articles about 5-[2-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-cyclopropylmethanesulfonyl]-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 86-93-1
1-Phenyl-1H-tetrazole-5-thiol

: 406684-10-4
[(1S,2S,3S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-cyclopropyl]-methanol

: 1026355-03-2
5-[2-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-cyclopropylmethanesulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: 1-Phenyl-1H-tetrazole-5-thiol; [(1S,2S,3S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-cyclopropyl]-methanol; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1002/1521-3773(20020104)41:1<176::AID-ANIE176>3.0.CO;2-#

Reference yield:

: 153618-35-0
menthyl (1S,2S,3S)-2-hydroxymethyl-3-methylcyclopropane-1-carboxylate

: 1026355-03-2
5-[2-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-cyclopropylmethanesulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: imidazole / CH₂Cl₂ / 0.5 h / 20 °C

2.1: LiAlH₄ / diethyl ether / 1 h / 0 °C

3.1: imidazole / CH₂Cl₂ / 1 h / 20 °C

4.1: camphorsulfonic acid / methanol / 0.67 h / 0 °C

5.1: diisopropyl azodicarboxylate; P(C₆H₅)3 / tetrahydrofuran / 0.08 h / 0 °C

5.2: 86 percent / MCPBA / CH₂Cl₂ / 0.5 h / 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 5.1: Mitsunobu reaction;
DOI:10.1002/1521-3773(20020104)41:1<176::AID-ANIE176>3.0.CO;2-#

Reference yield:

: [(1S,2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclopropyl]-methanol

: 1026355-03-2
5-[2-(tert-butyl-diphenyl-silanyloxymethyl)-3-methyl-cyclopropylmethanesulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: imidazole / CH₂Cl₂ / 1 h / 20 °C

2.1: camphorsulfonic acid / methanol / 0.67 h / 0 °C

3.1: diisopropyl azodicarboxylate; P(C₆H₅)3 / tetrahydrofuran / 0.08 h / 0 °C

3.2: 86 percent / MCPBA / CH₂Cl₂ / 0.5 h / 0 °C

With 1H-imidazole; di-isopropyl azodicarboxylate; triphenylphosphine; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; 3.1: Mitsunobu reaction;
DOI:10.1002/1521-3773(20020104)41:1<176::AID-ANIE176>3.0.CO;2-#