2,2-dichloro-N-[1-hydroxymethyl-2-methoxy-2-(4-methanesulfonyl-phenyl)-ethyl]-acetamide

Base Information

Chemical Name:2,2-dichloro-N-[1-hydroxymethyl-2-methoxy-2-(4-methanesulfonyl-phenyl)-ethyl]-acetamide
CAS No.:912296-98-1
Molecular Formula:C₁₃H₁₇Cl₂NO₅S
Molecular Weight:370.254
Hs Code.:

Synonyms:2,2-dichloro-N-[1-hydroxymethyl-2-methoxy-2-(4-methanesulfonyl-phenyl)-ethyl]-acetamide

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Chemical Property of 2,2-dichloro-N-[1-hydroxymethyl-2-methoxy-2-(4-methanesulfonyl-phenyl)-ethyl]-acetamide

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Technology Process of 2,2-dichloro-N-[1-hydroxymethyl-2-methoxy-2-(4-methanesulfonyl-phenyl)-ethyl]-acetamide

There total 5 articles about 2,2-dichloro-N-[1-hydroxymethyl-2-methoxy-2-(4-methanesulfonyl-phenyl)-ethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 912296-97-0
syn-(2R,3R)-[2-amino-3-methoxy-3-(4-methanesulfonyl-phenyl)-1-propanol]

: 116-54-1
dichloroacetic acid methyl ester

: 912296-98-1
2,2-dichloro-N-[1-hydroxymethyl-2-methoxy-2-(4-methanesulfonyl-phenyl)-ethyl]-acetamide

Guidance literature:: at 90 ℃; for 1h;
DOI:10.1016/j.tet.2006.07.014

Reference yield:

: (E)-1-((1S,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(4-methylsulfanyl-phenyl)-propenone

: 912296-98-1
2,2-dichloro-N-[1-hydroxymethyl-2-methoxy-2-(4-methanesulfonyl-phenyl)-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 92 percent / magnesium mono peroxy phthalate / methanol / 2 h / 20 °C

2.1: 68 percent / AgNO₃; Br₂ / 0.5 h / 0 °C

3.1: 92 percent / NaN₃ / dimethylformamide / 4 h / 60 °C

4.1: LiBH₄ / tetrahydrofuran; methanol

4.2: 82 percent / PPh₃ / tetrahydrofuran; H₂O / 5 h / 25 °C

5.1: 85 percent / 1 h / 90 °C

With lithium borohydride; sodium azide; magnesium bis(monoperoxyphthalate)hexahydrate; bromine; silver nitrate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.07.014

Reference yield:

: (2R)-N-[(2-methanesulfonyl-phenyl)-propenoyl]-bornanesultam

: 912296-98-1
2,2-dichloro-N-[1-hydroxymethyl-2-methoxy-2-(4-methanesulfonyl-phenyl)-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 68 percent / AgNO₃; Br₂ / 0.5 h / 0 °C

2.1: 92 percent / NaN₃ / dimethylformamide / 4 h / 60 °C

3.1: LiBH₄ / tetrahydrofuran; methanol

3.2: 82 percent / PPh₃ / tetrahydrofuran; H₂O / 5 h / 25 °C

4.1: 85 percent / 1 h / 90 °C

With lithium borohydride; sodium azide; bromine; silver nitrate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.07.014