Technology Process of (S)-N-benzyl-2-fluoro-3-phenylpropan-1-amine
There total 4 articles about (S)-N-benzyl-2-fluoro-3-phenylpropan-1-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tris(acetoxy)borohydride;
In
1,2-dichloro-ethane;
at 23 ℃;
optical yield given as %ee;
enantioselective reaction;
DOI:10.1021/ol802930q
- Guidance literature:
-
Multi-step reaction with 3 steps
1: C18H13Br3N3O(1+)*BF4(1-); N-fluorobis(benzenesulfon)imide; sodium acetate / 1,4-dioxane / 24 h / 24 °C / Schlenk technique; Inert atmosphere
2: diisobutylaluminium hydride / dichloromethane; toluene / 0.33 h / -78 °C / Inert atmosphere
3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 24 °C
With
C18H13Br3N3O(1+)*BF4(1-); sodium acetate; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; N-fluorobis(benzenesulfon)imide;
In
1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1002/anie.201409473
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: C18H13Br3N3O(1+)*BF4(1-); N-fluorobis(benzenesulfon)imide; sodium acetate / 1,4-dioxane / 0.17 h / 24 °C / Schlenk technique; Inert atmosphere
1.2: 14 h / 24 °C / Inert atmosphere; Schlenk technique
2.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.33 h / -78 °C / Inert atmosphere
3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 24 °C
With
C18H13Br3N3O(1+)*BF4(1-); sodium acetate; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; N-fluorobis(benzenesulfon)imide;
In
1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1002/anie.201409473
