(S)-(-)-2-fluoro-3-phenylpropionaldehyde

Base Information

Chemical Name:(S)-(-)-2-fluoro-3-phenylpropionaldehyde
CAS No.:862668-88-0
Molecular Formula:C₉H₉FO
Molecular Weight:152.168
Hs Code.:

Synonyms:(S)-(-)-2-fluoro-3-phenylpropionaldehyde

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Chemical Property of (S)-(-)-2-fluoro-3-phenylpropionaldehyde

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Technology Process of (S)-(-)-2-fluoro-3-phenylpropionaldehyde

There total 7 articles about (S)-(-)-2-fluoro-3-phenylpropionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 141022-95-9
(2S)-2-fluoro-3-phenylpropan-1-ol

: 862668-88-0
(S)-(-)-2-fluoro-3-phenylpropionaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; at -78 - 0 ℃; for 2h;
DOI:10.1039/d0sc04032k

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 862668-88-0
(S)-(-)-2-fluoro-3-phenylpropionaldehyde

Guidance literature:: With 5-benzyl-2,2,3-trimethylimidazolidin-4-one dichloroacetic acid salt; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; isopropyl alcohol; at -20 ℃; for 24h; enantioselective reaction;
DOI:10.1021/ol802930q

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 862668-88-0
(S)-(-)-2-fluoro-3-phenylpropionaldehyde

: 1095607-09-2
(R)-2-fluoro-3-phenylpropionaldehyde

Guidance literature:: With (R,R)-2,5-diphenylpyrrolidine; N-fluorobis(benzenesulfon)imide; In dichloromethane; at 20 ℃; for 1h; Further Variations:; Reagents; Solvents; Product distribution;
DOI:10.1002/anie.200500395