Technology Process of (S)-2-(2-(1-hydroxy-1-phenyl)propyl)isoindole-1,3-dione
There total 3 articles about (S)-2-(2-(1-hydroxy-1-phenyl)propyl)isoindole-1,3-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-((S)-1-methyl-2-oxo-2-phenyl-ethyl)-phthalimide;
With
aluminum isopropoxide;
In
isopropyl alcohol; toluene;
at 60 ℃;
for 72h;
With
hydrogenchloride; water;
In
isopropyl alcohol; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine / toluene / 24 h / Reflux
2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 h / 10 - 20 °C / cooling with ice-water
3: aluminum (III) chloride / dichloromethane / 24 h / 10 - 20 °C / cooling with ice-water
4: aluminum isopropoxide / isopropyl alcohol; toluene / 72 h / 60 °C
With
oxalyl dichloride; aluminum isopropoxide;
aluminum (III) chloride; triethylamine; N,N-dimethyl-formamide;
In
dichloromethane; isopropyl alcohol; toluene;
3: Friedel Crafts Acylation;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 h / 10 - 20 °C / cooling with ice-water
2: aluminum (III) chloride / dichloromethane / 24 h / 10 - 20 °C / cooling with ice-water
3: aluminum isopropoxide / isopropyl alcohol; toluene / 72 h / 60 °C
With
oxalyl dichloride; aluminum isopropoxide;
aluminum (III) chloride; N,N-dimethyl-formamide;
In
dichloromethane; isopropyl alcohol; toluene;
2: Friedel Crafts Acylation;
