4192-28-3Relevant articles and documents
Synthesis, spectroscopic characterization, and antifungal activity of some mixed ligand complexes of Zn(II), Cd(II), and Hg(II)
Sharma, Renu,Nagar, Meena
, p. 1526 - 1535 (2010)
A series of new mixed ligand complexes of Zn(II), Cd(II), and Hg(II) with citronellal thiosemicarbazone [3,7-dimethyl-6-octene-1-a1 thiosemicarbazone (LH)] and N-phthaloyl amino acids (AH) have been synthesized by the reaction of metal(II) chloride with ligands citronellal thiosemicarbazone (DOTSC) and N-phthaloyl glycine [1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetic acid (A1H)] or N-phthaloyl alanine [1,3-dihydro-1,3-dioxo-(methyl)-2H-isoindole-2-acetic acid (A2H)] in 1:1:1 molar ratio in dry refluxing ethanol. All the complexes have been characterized by elemental analyses, molar conductance measurement, molecular weight measurement, IR, and multinuclear NMR (1H and 13C{1H}) spectral studies. IR, 1H, and 13C{1H} NMR spectral studies suggest the involvement of azomethine-N, thiol-S atoms of the thiosemicarbazone moiety and both carboxylate-O of N-phthaloyl amino acid moiety in coordination with central metal(II) ion, and four coordinated geometries have been assigned to these complexes. The free ligands and metal complexes have been screened for their antifungal activity against two fungal strains, Fusarium moniliformae and Macrophomina phaseolina, using the the radial growth method. The results of antifungal activity show that metal complexes show enhanced higher activity than the free ligands. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. Copyright Taylor & Francis Group, LLC.
Dynamic kinetic resolution utilizing 2-oxoimidazolidine-4-carboxylate as a chiral auxiliary: Stereoselective synthesis of α-amino acids by Gabriel reaction
Kubo, Akira,Kubota, Hitoshi,Takahashi, Masami,Nunami, Ken-Ichi
, p. 4957 - 4960 (1996)
A Highly stereoselective Gabriel reaction via dynamic kinetic resolution utilizing 2-oxoimidazolidine-4-carboxylate as a chiral auxiliary was exploited. The reaction of tert-butyl (4S)-1-methyl-3-(2-bromopropionyl)-2- oxoimidazolidine-4-carboxylate (2a) w
AMINO ACID DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES
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Page/Page column 31, (2020/08/13)
The present disclosure provides certain amino acid derivatives that inhibit NF-kB activation and are therefore useful for the treatment of inflammatory diseases. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
1-Aminopyridinium Ylides as Monodentate Directing Groups for sp3 C-H Bond Functionalization
Le, Ky Khac Anh,Nguyen, Hanh,Daugulis, Olafs
supporting information, p. 14728 - 14735 (2019/10/11)
1-Aminopyridinium ylides are efficient directing groups for palladium-catalyzed β-arylation and alkylation of sp3 C-H bonds in carboxylic acid derivatives. The efficiency of these directing groups depends on the substitution at the pyridine moiety. The unsubstituted pyridine-derived ylides allow functionalization of primary C-H bonds, while methylene groups are unreactive in the absence of external ligands. 4-Pyrrolidinopyridine-containing ylides are capable of C-H functionalization in acyclic methylene groups in the absence of external ligands, thus rivaling the efficiency of the aminoquinoline directing group. Preliminary mechanistic studies have been performed. A cyclopalladated intermediate has been isolated and characterized by X-ray crystallography, and its reactivity was studied.