methyl 2-(3-((3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-3-methoxyacrylate

Base Information

Chemical Name:methyl 2-(3-((3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-3-methoxyacrylate
CAS No.:1316307-86-4
Molecular Formula:C₂₃H₂₀ClN₃O₅
Molecular Weight:453.882
Hs Code.:

Synonyms:methyl 2-(3-((3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-3-methoxyacrylate

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Chemical Property of methyl 2-(3-((3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-3-methoxyacrylate

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Technology Process of methyl 2-(3-((3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-3-methoxyacrylate

There total 7 articles about methyl 2-(3-((3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-3-methoxyacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1316307-82-0
methyl 2-(3-allyl-4-oxo-3,4-dihydro-phthalazin-1-yl)-3-methoxyacrylate

: 3848-36-0
4-chlorobenzaldoxime

: 1316307-86-4
methyl 2-(3-((3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-3-methoxyacrylate

Guidance literature:: 4-chlorobenzaldoxime; With N-chloro-succinimide; potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 0.5h;

methyl 2-(3-allyl-4-oxo-3,4-dihydro-phthalazin-1-yl)-3-methoxyacrylate; In N,N-dimethyl-formamide; at 60 ℃; for 4h;
DOI:10.1590/S0103-50532011000500006

Reference yield:

: 85-44-9
phthalic anhydride

: 1316307-86-4
methyl 2-(3-((3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-3-methoxyacrylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium acetate / 135 - 140 °C

2.1: hydrazine hydrate / methanol / Reflux

3.1: sulfuric acid

4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 60 - 65 °C

5.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 7 h / 0 - 10 °C / Inert atmosphere

6.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 0 - 20 °C / Inert atmosphere

7.1: N-chloro-succinimide; potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C

7.2: 4 h / 60 °C

With N-chloro-succinimide; sulfuric acid; potassium acetate; sodium hydride; potassium carbonate; hydrazine hydrate; In methanol; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1590/S0103-50532011000500006

Reference yield:

: 84703-24-2
methyl 2-(3-allyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetate

: 1316307-86-4
methyl 2-(3-((3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-3-methoxyacrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 7 h / 0 - 10 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 0 - 20 °C / Inert atmosphere

3.1: N-chloro-succinimide; potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C

3.2: 4 h / 60 °C

With N-chloro-succinimide; sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; paraffin oil;
DOI:10.1590/S0103-50532011000500006