1-[(tert-butoxycarbonyl)amino]-3-(dimethoxyphosphoryl)-propan-2-yl 4-nitrobenzoate

Base Information

Chemical Name:1-[(tert-butoxycarbonyl)amino]-3-(dimethoxyphosphoryl)-propan-2-yl 4-nitrobenzoate
CAS No.:1399822-76-4
Molecular Formula:C₁₇H₂₅N₂O₉P
Molecular Weight:432.367
Hs Code.:

Synonyms:1-[(tert-butoxycarbonyl)amino]-3-(dimethoxyphosphoryl)-propan-2-yl 4-nitrobenzoate

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Chemical Property of 1-[(tert-butoxycarbonyl)amino]-3-(dimethoxyphosphoryl)-propan-2-yl 4-nitrobenzoate

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Technology Process of 1-[(tert-butoxycarbonyl)amino]-3-(dimethoxyphosphoryl)-propan-2-yl 4-nitrobenzoate

There total 2 articles about 1-[(tert-butoxycarbonyl)amino]-3-(dimethoxyphosphoryl)-propan-2-yl 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.8%

: 1104662-21-6
(R)-2-hydroxy-3-(N-tert-butoxycarbonylamino)dimethoxyphosphorylpropane

: 122-04-3
4-nitro-benzoyl chloride

: 1399822-76-4
1-[(tert-butoxycarbonyl)amino]-3-(dimethoxyphosphoryl)-propan-2-yl 4-nitrobenzoate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 26 - 30 ℃; for 8h; Inert atmosphere;
DOI:10.1021/jo301532t

Reference yield:

: 112392-58-2
dimethyl 2-oxo-3-(N-tert-butoxycarbonylamino)propane phosphonate

: 1399822-76-4
1-[(tert-butoxycarbonyl)amino]-3-(dimethoxyphosphoryl)-propan-2-yl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: C₄₈H₄₄ClO₄P₂Ru⁽¹⁺⁾*Cl^(1-); hydrogen / methanol / 19 h / 50 °C / 7500.75 Torr / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 8 h / 26 - 30 °C / Inert atmosphere

With dmap; C₄₈H₄₄ClO₄P₂Ru⁽¹⁺⁾*Cl^(1-); hydrogen; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jo301532t