(R)-2-Methyl-1-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-phenyl-propane-1,3-dione

Base Information

• Chemical Name: (R)-2-Methyl-1-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-phenyl-propane-1,3-dione
• CAS No.: 88636-03-7
• Molecular Formula: C₂₀H₁₉NO₄
• Molecular Weight: 337.375

Synonyms:(R)-2-Methyl-1-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-phenyl-propane-1,3-dione

Chemical Property of (R)-2-Methyl-1-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-phenyl-propane-1,3-dione

Chemical Property:

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Technology Process of (R)-2-Methyl-1-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-phenyl-propane-1,3-dione

There total 2 articles about (R)-2-Methyl-1-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-phenyl-propane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one (77877-20-4) → (R)-2-Methyl-1-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-phenyl-propane-1,3-dione (88636-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium diisopropylamide

2: tetrahydrofuran / -78 °C

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1021/ja00316a077

Reference yield:

benzoyl chloride (98-88-4) + Lithium; (Z)-1-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-propen-1-olate → (4R,5S,2'S)-3-(2'-benzoylpropanoyl)-4-methyl-5-phenyl-2-oxazolidinone (88635-97-6) + (R)-2-Methyl-1-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-phenyl-propane-1,3-dione (88636-03-7)

Guidance literature:

In tetrahydrofuran; at -78 ℃; Yield given;

DOI:10.1021/ja00316a077

Reference yield:

(R)-2-Methyl-1-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-phenyl-propane-1,3-dione (88636-03-7) → (4R,5S)-3-((2R,3R)-3-Hydroxy-2-methyl-3-phenyl-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one (77877-26-0)

Guidance literature:

With zinc borohydride; In diethyl ether; dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1021/ja00316a077

upstream raw materials:

benzoyl chloride

(4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one

Downstream raw materials:

(4R,5S)-3-((2R,3R)-3-Hydroxy-2-methyl-3-phenyl-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one

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