3-chloro-benzoic acid-((1R)-menthyl ester)

Base Information

• Chemical Name: 3-chloro-benzoic acid-((1R)-menthyl ester)
• CAS No.: 125553-47-1
• Molecular Formula: C₁₇H₂₃ClO₂
• Molecular Weight: 294.821
• Mol file: 125553-47-1.mol

Synonyms:3-chloro-benzoic acid-((1R)-menthyl ester)

Chemical Property of 3-chloro-benzoic acid-((1R)-menthyl ester)

Chemical Property:

Purity/Quality:

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Technology Process of 3-chloro-benzoic acid-((1R)-menthyl ester)

There total 1 articles about 3-chloro-benzoic acid-((1R)-menthyl ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.6%

(-)-menthol (2216-51-5) + m-Chlorobenzoyl chloride (618-46-2) → 3-chloro-benzoic acid-((1R)-menthyl ester) (125553-47-1)

Guidance literature:

With pyridine; In tetrahydrofuran; Reflux;

DOI:10.1007/s00044-011-9550-3

Reference yield:

Methyl p-tolyl sulfoxide (934-72-5) + 3-chloro-benzoic acid-((1R)-menthyl ester) (125553-47-1) → 4-[2-(Toluene-4-sulfinyl)-acetyl]-benzonitrile

Guidance literature:

With lithium diethylamide; In tetrahydrofuran; Product distribution; determination of e.e. (3.7percent);

DOI:10.1246/bcsj.62.2229

upstream raw materials:

(-)-menthol

m-Chlorobenzoyl chloride

Refernces

• 1、 Kunieda, Norio,Nakanishi, Takeshi,Kinoshita, Masayoshi. "Substituent Effect on the Enantiomer-Differentiating Reaction of Lithiomethyl p-Tolyl Sulfoxide with Meta- or Para-Substituted (R)-(-)-Menthyl Benzoates". . p. 2229 - 2234. Retrieved 2007/10/02.