[(1S)-1-(N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinocarbonyl)-3-carbamoylpropyl]carbamic acid tert-butyl ester

Base Information

Chemical Name:[(1S)-1-(N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinocarbonyl)-3-carbamoylpropyl]carbamic acid tert-butyl ester
CAS No.:1346444-92-5
Molecular Formula:C₃₄H₃₉N₅O₁₀S
Molecular Weight:709.777
Hs Code.:

[(1S)-1-(N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinocarbonyl)-3-carbamoylpropyl]carbamic acid tert-butyl ester

Synonyms:[(1S)-1-(N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinocarbonyl)-3-carbamoylpropyl]carbamic acid tert-butyl ester

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Chemical Property of [(1S)-1-(N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinocarbonyl)-3-carbamoylpropyl]carbamic acid tert-butyl ester

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Technology Process of [(1S)-1-(N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinocarbonyl)-3-carbamoylpropyl]carbamic acid tert-butyl ester

There total 8 articles about [(1S)-1-(N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinocarbonyl)-3-carbamoylpropyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 15387-45-8
Boc-Gln-ONp

: C₂₄H₂₃N₃O₆S

: 1346444-92-5
[(1S)-1-(N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinocarbonyl)-3-carbamoylpropyl]carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.09.062

Reference yield:

: 1346444-76-5
N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinecarboxylic acid tert-butyl ester

: 1346444-92-5
[(1S)-1-(N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinocarbonyl)-3-carbamoylpropyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / 1.5 h / 0 °C / Inert atmosphere

1.2: 0.05 h / Inert atmosphere

2.1: benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With benzotriazol-1-ol; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.09.062

Reference yield:

: 1346444-69-6
2,4-dimethyl-6-(2-nitrobenzyloxy)benzaldehyde

: 1346444-92-5
[(1S)-1-(N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinocarbonyl)-3-carbamoylpropyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: piperidine; acetic acid / toluene / 18 h / Inert atmosphere; Reflux

2.1: trifluoroacetic acid / 1.5 h / 0 °C / Inert atmosphere

2.2: 0.05 h / Inert atmosphere

3.1: benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With piperidine; benzotriazol-1-ol; acetic acid; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide; toluene; 1.1: Knoevenagel condensation;
DOI:10.1016/j.tet.2011.09.062