15387-45-8 Usage
Description
BOC-GLN-ONP, also known as N-(tert-butoxycarbonyl)-L-glutamine p-nitroanilide, is a synthetic compound that serves as an amino acid building block used in chemical synthesis and peptide chemistry. It is a white powder with specific chemical properties that make it suitable for various applications.
Uses
Used in Pharmaceutical Industry:
BOC-GLN-ONP is used as a substrate for cathepsin B, a lysosomal protease enzyme that plays a crucial role in various biological processes, including protein degradation and antigen presentation. Its use as a substrate helps in the study and development of inhibitors for cathepsin B, which can be beneficial in the treatment of various diseases, such as cancer and neurodegenerative disorders.
Used in Chemical Synthesis and Peptide Chemistry:
BOC-GLN-ONP is used as an amino acid building block in the synthesis of peptides and other complex molecules. Its unique structure allows for the formation of peptide bonds and the creation of diverse peptide sequences with potential applications in drug development, diagnostics, and research.
Used in Research and Development:
BOC-GLN-ONP is utilized in research and development for the study of enzyme kinetics, protein-protein interactions, and the development of novel therapeutic agents. Its role as a substrate and building block enables researchers to investigate the mechanisms of various biological processes and design targeted therapies for specific diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 15387-45-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,3,8 and 7 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 15387-45:
(7*1)+(6*5)+(5*3)+(4*8)+(3*7)+(2*4)+(1*5)=118
118 % 10 = 8
So 15387-45-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H21N3O7/c1-16(2,3)26-15(22)18-12(8-9-13(17)20)14(21)25-11-6-4-10(5-7-11)19(23)24/h4-7,12H,8-9H2,1-3H3,(H2,17,20)(H,18,22)/t12-/m0/s1
15387-45-8Relevant articles and documents
Peptide coupling of unprotected amino acids through in situ p-nitrophenyl ester formation
Gagnon, Paul,Huang, Xicai,Therrien, Eric,Keillor, Jeffrey W.
, p. 7717 - 7719 (2007/10/03)
Several series of dipeptides and tripeptides were prepared via an activation-coupling method involving the in situ formation of a p-nitrophenyl ester of an (N-protected) amino acid, followed by coupling with an unprotected amino acid in partially aqueous solutions. The resulting peptide is easily isolated by precipitation. In general, the yields obtained are good to excellent and racemization is minimal. This method is particularly advantageous with respect to its simplicity and lack of obligatory side chain protection/deprotection steps.
