allyl 2(S)-acetylamino-3-<<4(S)-<(tert-butyloxycarbonyl)amino>-5-<(4-tert-butyloxy)phenyl>pent-2(E)-enoyl>amino>propanoate

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Chemical Name:allyl 2(S)-acetylamino-3-<<4(S)-<(tert-butyloxycarbonyl)amino>-5-<(4-tert-butyloxy)phenyl>pent-2(E)-enoyl>amino>propanoate
CAS No.:171109-50-5
Molecular Formula:C₂₈H₄₁N₃O₇
Molecular Weight:531.649
Hs Code.:

Synonyms:allyl 2(S)-acetylamino-3-<<4(S)-<(tert-butyloxycarbonyl)amino>-5-<(4-tert-butyloxy)phenyl>pent-2(E)-enoyl>amino>propanoate

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Chemical Property of allyl 2(S)-acetylamino-3-<<4(S)-<(tert-butyloxycarbonyl)amino>-5-<(4-tert-butyloxy)phenyl>pent-2(E)-enoyl>amino>propanoate

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Technology Process of allyl 2(S)-acetylamino-3-<<4(S)-<(tert-butyloxycarbonyl)amino>-5-<(4-tert-butyloxy)phenyl>pent-2(E)-enoyl>amino>propanoate

There total 5 articles about allyl 2(S)-acetylamino-3-<<4(S)-<(tert-butyloxycarbonyl)amino>-5-<(4-tert-butyloxy)phenyl>pent-2(E)-enoyl>amino>propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.8%

: 171109-54-9
4(S)-<(tert-butyloxycarbonyl)amino>-5-<(4-tert-butyloxy)phenyl>pent-2(E)-enoic acid

: allyl 2(S)-(acetylamino)-3-aminopropanoate hydrochloride

: 171109-50-5
allyl 2(S)-acetylamino-3-<<4(S)-<(tert-butyloxycarbonyl)amino>-5-<(4-tert-butyloxy)phenyl>pent-2(E)-enoyl>amino>propanoate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1.5h; Ambient temperature;
DOI:10.1021/jo961447m

Reference yield:

: 74974-37-1
tert-butyl N-[(1S)-1-[(4-tert-butoxyphenyl)methyl]-2-oxoethyl]carbamate

: 171109-50-5
allyl 2(S)-acetylamino-3-<<4(S)-<(tert-butyloxycarbonyl)amino>-5-<(4-tert-butyloxy)phenyl>pent-2(E)-enoyl>amino>propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 93.7 percent / NaH / tetrahydrofuran / 1.) room temperature, 10 min, 2.) -50 deg C, 30 min; 10 deg C, 2.5 h

2: 97.5 percent / 1N NaOH / dioxane; H₂O / 14 h

3: 98.8 percent / DIPEA, TBTU / CH₂Cl₂ / 1.5 h / Ambient temperature

With sodium hydroxide; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jo961447m

Reference yield:

: 190203-26-0
ethyl 4(S)-<(tert-butyloxycarbonyl)amino>-5-<(4-tert-butyloxy)phenyl>pent-2(E)-enoate

: 171109-50-5
allyl 2(S)-acetylamino-3-<<4(S)-<(tert-butyloxycarbonyl)amino>-5-<(4-tert-butyloxy)phenyl>pent-2(E)-enoyl>amino>propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 97.5 percent / 1N NaOH / dioxane; H₂O / 14 h

2: 98.8 percent / DIPEA, TBTU / CH₂Cl₂ / 1.5 h / Ambient temperature

With sodium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jo961447m