(S)-5-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}aminonicotinonitrile

Base Information

Chemical Name:(S)-5-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}aminonicotinonitrile
CAS No.:1239359-87-5
Molecular Formula:C₂₂H₁₇FN₈
Molecular Weight:412.429
Hs Code.:

Synonyms:(S)-5-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}aminonicotinonitrile

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Chemical Property of (S)-5-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}aminonicotinonitrile

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Technology Process of (S)-5-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}aminonicotinonitrile

There total 4 articles about (S)-5-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}aminonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5049-61-6
2-Aminopyrazine

: 1239363-14-4
(S)-5-{6-chloro-2-[1-(4-fluorophenyl)ethylamino]pyrimidin-4-yl}nicotinonitrile

: 1239359-87-5
(S)-5-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}aminonicotinonitrile

Guidance literature:: With sodium t-butanolate; XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 35590-37-5
5-bromopyridine-3-carbonitrile

: 1239359-87-5
(S)-5-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}aminonicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 89 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / toluene / 17 h / 110 °C / Inert atmosphere

3: sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; XPhos / toluene / 1 h / 89 °C / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium t-butanolate; XPhos; In 1,4-dioxane; toluene;

Reference yield:

: 66399-30-2
(S)-1-(4-Fluoro-phenyl)-ethylamine

: 1239359-87-5
(S)-5-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}aminonicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 9.5 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / toluene / 17 h / 110 °C / Inert atmosphere

3: sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; XPhos / toluene / 1 h / 89 °C / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; sodium t-butanolate; XPhos; In tetrahydrofuran; toluene;