5-bromo-1-(2,6-difluoro-benzyl)-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione

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Chemical Name:5-bromo-1-(2,6-difluoro-benzyl)-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
CAS No.:552291-24-4
Molecular Formula:C₂₁H₂₁BrF₂N₄O₂
Molecular Weight:479.324
Hs Code.:

5-bromo-1-(2,6-difluoro-benzyl)-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1<i>H</i>-pyrimidine-2,4-dione

Synonyms:5-bromo-1-(2,6-difluoro-benzyl)-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione

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Chemical Property of 5-bromo-1-(2,6-difluoro-benzyl)-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione

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Technology Process of 5-bromo-1-(2,6-difluoro-benzyl)-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione

There total 3 articles about 5-bromo-1-(2,6-difluoro-benzyl)-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 5638-76-6
betahistine

: 552291-23-3
[5-bromo-3-(2,6-difluoro-benzyl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-acetaldehyde

: 552291-24-4
5-bromo-1-(2,6-difluoro-benzyl)-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane;
DOI:10.1021/jm034041s

Reference yield:

: 352304-09-7
5-bromo-1-(2,6-difluorobenzyl)uracil

: 552291-24-4
5-bromo-1-(2,6-difluoro-benzyl)-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 49 percent / K₂CO₃ / dimethylformamide

2: 85 percent / aq. NaIO₄; OsO₄ / tetrahydrofuran

3: 80 percent / NaBH(OAc)3 / CH₂Cl₂

With sodium periodate; osmium(VIII) oxide; sodium tris(acetoxy)borohydride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm034041s

Reference yield:

: 552291-22-2
3-allyl-5-bromo-1-(2,6-difluoro-benzyl)-1H-pyrimidine-2,4-dione

: 552291-24-4
5-bromo-1-(2,6-difluoro-benzyl)-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / aq. NaIO₄; OsO₄ / tetrahydrofuran

2: 80 percent / NaBH(OAc)3 / CH₂Cl₂

With sodium periodate; osmium(VIII) oxide; sodium tris(acetoxy)borohydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm034041s