4-Propionyl-piperidine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide

Base Information

Chemical Name:4-Propionyl-piperidine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide
CAS No.:86543-17-1
Molecular Formula:C₁₈H₂₃N₃O₃S
Molecular Weight:361.465
Hs Code.:

Synonyms:4-Propionyl-piperidine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide

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Chemical Property of 4-Propionyl-piperidine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide

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Technology Process of 4-Propionyl-piperidine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide

There total 4 articles about 4-Propionyl-piperidine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 86542-94-1
1-(piperidine-4-yl)-propan-1-one

: 43091-89-0
2-isothiocyanato-4,5-dimethoxybenzonitrile

: 86543-17-1
4-Propionyl-piperidine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide

Guidance literature:: In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1021/jm00364a014

Reference yield:

: 62718-31-4
1-benzylpiperidine-4-carbonitrile

: 86543-17-1
4-Propionyl-piperidine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / a) reflux, 3 h, b) RT, overnight

2: 1 N aq. HCl, H₂ / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

3: 60 percent / dimethylformamide / 0 °C

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a014

Reference yield:

: 62992-68-1
1-benzyl-piperidine-4-carboxylic acid amide

: 86543-17-1
4-Propionyl-piperidine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / thionyl chloride / 3 h / Heating

2: tetrahydrofuran / a) reflux, 3 h, b) RT, overnight

3: 1 N aq. HCl, H₂ / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

4: 60 percent / dimethylformamide / 0 °C

With hydrogenchloride; thionyl chloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a014