tert-butyl({(R)-1-[(2R,3R)-3-ethynyloxiran-2-yl]propan-2-yl}oxy)-diphenylsilane

Base Information

Chemical Name:tert-butyl({(R)-1-[(2R,3R)-3-ethynyloxiran-2-yl]propan-2-yl}oxy)-diphenylsilane
CAS No.:1622322-52-4
Molecular Formula:C₂₃H₂₈O₂Si
Molecular Weight:364.56
Hs Code.:

Synonyms:tert-butyl({(R)-1-[(2R,3R)-3-ethynyloxiran-2-yl]propan-2-yl}oxy)-diphenylsilane

Suppliers and Price of tert-butyl({(R)-1-[(2R,3R)-3-ethynyloxiran-2-yl]propan-2-yl}oxy)-diphenylsilane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl({(R)-1-[(2R,3R)-3-ethynyloxiran-2-yl]propan-2-yl}oxy)-diphenylsilane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl({(R)-1-[(2R,3R)-3-ethynyloxiran-2-yl]propan-2-yl}oxy)-diphenylsilane

There total 1 articles about tert-butyl({(R)-1-[(2R,3R)-3-ethynyloxiran-2-yl]propan-2-yl}oxy)-diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 90965-06-3
dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

: 303044-46-4
(-)-(2R,3R,5R)-5-(tert-butyldiphenylsilyloxy)-2,3-(oxiranyl)-hexan-1-al

: 1622322-52-4
tert-butyl({(R)-1-[(2R,3R)-3-ethynyloxiran-2-yl]propan-2-yl}oxy)-diphenylsilane

Guidance literature:: With potassium carbonate; In methanol; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1002/ejoc.201402205

Reference yield: 98.0%

: 1622322-52-4
tert-butyl({(R)-1-[(2R,3R)-3-ethynyloxiran-2-yl]propan-2-yl}oxy)-diphenylsilane

: 1622322-54-6
tert-butyl({(R)-1-[(2R,3R)-3-(iodoethynyl)oxiran-2-yl]propan-2-yl}oxy)diphenylsilane

Guidance literature:: With N-iodo-succinimide; silver nitrate; In acetone; at 25 ℃; for 1h; Inert atmosphere; Darkness;
DOI:10.1002/ejoc.201402205

Reference yield:

: 1622322-52-4
tert-butyl({(R)-1-[(2R,3R)-3-ethynyloxiran-2-yl]propan-2-yl}oxy)-diphenylsilane

: 6-(5-{2-[(1E,3Z)-4-{(2R,3R)-3-[(R)-2-(tert-butyldiphenylsilyloxy)-propyl]oxiran-2-yl}buta-1,3-dien-1-yl]-1,3-dioxolan-2-yl}-4-hydroxy-2-oxopentyl)-2,2-dimethyl-4H-1,3-dioxin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-iodo-succinimide; silver nitrate / acetone / 1 h / 25 °C / Inert atmosphere; Darkness

2.1: 2-nitrobenzenesulfonyl hydrazide; triethylamine / tetrahydrofuran; isopropyl alcohol / 40 h / 25 °C / Inert atmosphere; Darkness

3.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 7 h / 55 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

5.1: Dess-Martin periodane / dichloromethane / 2 h / 25 °C / Inert atmosphere

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - -40 °C / Inert atmosphere

6.2: 3 h / -40 °C / Inert atmosphere

6.3: -40 - 25 °C / Inert atmosphere

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-nitrobenzenesulfonyl hydrazide; tetrabutyl ammonium fluoride; caesium carbonate; Dess-Martin periodane; silver nitrate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; acetone; 3.1: |Suzuki Coupling;
DOI:10.1002/ejoc.201402205