5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-[(4-methoxyphenyl)thio]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Base Information

Chemical Name:5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-[(4-methoxyphenyl)thio]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide
CAS No.:1354917-52-4
Molecular Formula:C₂₄H₂₁ClFN₃O₅S₃
Molecular Weight:582.097
Hs Code.:

Synonyms:5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-[(4-methoxyphenyl)thio]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

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Chemical Property of 5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-[(4-methoxyphenyl)thio]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

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Technology Process of 5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-[(4-methoxyphenyl)thio]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

There total 4 articles about 5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-[(4-methoxyphenyl)thio]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 696-63-9
4-Methoxybenzenethiol

: 1235406-57-1
5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

: 1354917-52-4
5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-[(4-methoxyphenyl)thio]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Guidance literature:: With potassium carbonate; In ISOPROPYLAMIDE; at 20 ℃; for 1h;

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 1354917-52-4
5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-[(4-methoxyphenyl)thio]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triisopropoxytitanium(IV) chloride / dichloromethane / 1 h

1.2: 24 h

2.1: lithium bis(trimethylsilyl)azanide / 2-methyltetrahydrofuran / 1 h / -45 - -38 °C

2.2: 1.33 h / -45 - 15 °C

3.1: potassium carbonate / ISOPROPYLAMIDE / 1 h / 20 °C

With triisopropoxytitanium(IV) chloride; lithium bis(trimethylsilyl)azanide; potassium carbonate; In 2-methyltetrahydrofuran; dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: 13656-57-0
5-chloro-2,4-difluorobenzene-1-sulfonyl chloride

: 1354917-52-4
5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-4-[(4-methoxyphenyl)thio]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium bis(trimethylsilyl)azanide / 2-methyltetrahydrofuran / 1 h / -45 - -38 °C

1.2: 1.33 h / -45 - 15 °C

2.1: potassium carbonate / ISOPROPYLAMIDE / 1 h / 20 °C

With lithium bis(trimethylsilyl)azanide; potassium carbonate; In 2-methyltetrahydrofuran; ISOPROPYLAMIDE;