10-{(1E,3Z)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]buta-1,3-dien-1-yl}-N-(2-morpholin-4-ylethyl)-10H-phenothiazin-2-amine

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Chemical Name:10-{(1E,3Z)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]buta-1,3-dien-1-yl}-N-(2-morpholin-4-ylethyl)-10H-phenothiazin-2-amine
CAS No.:1401710-50-6
Molecular Formula:C₃₀H₃₁N₇O₂S
Molecular Weight:553.688
Hs Code.:

Synonyms:10-{(1E,3Z)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]buta-1,3-dien-1-yl}-N-(2-morpholin-4-ylethyl)-10H-phenothiazin-2-amine

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Chemical Property of 10-{(1E,3Z)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]buta-1,3-dien-1-yl}-N-(2-morpholin-4-ylethyl)-10H-phenothiazin-2-amine

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Technology Process of 10-{(1E,3Z)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]buta-1,3-dien-1-yl}-N-(2-morpholin-4-ylethyl)-10H-phenothiazin-2-amine

There total 1 articles about 10-{(1E,3Z)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]buta-1,3-dien-1-yl}-N-(2-morpholin-4-ylethyl)-10H-phenothiazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 742105-63-1
2-chloro-10-((1E,3Z)-4-(2-(4-methoxyphenyl)-2H-tetrazol-5-yl)buta-1,3-dien-1-yl)-10H-phenothiazine

: 1401710-50-6
10-{(1E,3Z)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]buta-1,3-dien-1-yl}-N-(2-morpholin-4-ylethyl)-10H-phenothiazin-2-amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; XPhos; In toluene; at 110 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.07.083

Reference yield: 26.0%

: 1401710-50-6
10-{(1E,3Z)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]buta-1,3-dien-1-yl}-N-(2-morpholin-4-ylethyl)-10H-phenothiazin-2-amine

: 1442371-63-2
4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-{2-[(2-morpholin-4-ylethyl)amino]-10H-phenothiazin-10-yl}butan-2-ol

Guidance literature:: 10-{(1E,3Z)-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]buta-1,3-dien-1-yl}-N-(2-morpholin-4-ylethyl)-10H-phenothiazin-2-amine; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃; for 24h;

With dihydrogen peroxide; sodium hydroxide; In methanol; water; at 0 - 20 ℃; for 24h;
DOI:10.1016/j.bmc.2013.04.034