2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethanol

Base Information

Chemical Name:2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethanol
CAS No.:1453208-66-6
Molecular Formula:C₁₈H₁₉F₂N₅O₄
Molecular Weight:407.377
Hs Code.:

Synonyms:2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethanol

Suppliers and Price of 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
ASP5878
2.5mg
$ 615.00

TRC
ASP5878
1mg
$ 285.00

DC Chemicals
ASP5878 >98%
1 g
$ 2800.00

DC Chemicals
ASP5878 >98%
250 mg
$ 1300.00

DC Chemicals
ASP5878 >98%
100 mg
$ 850.00

ChemScene
ASP5878 99.71%
5mg
$ 450.00

ChemScene
ASP5878 99.71%
10mg
$ 750.00

ChemScene
ASP5878 99.71%
100mg
$ 3300.00

ChemScene
ASP5878 99.71%
25mg
$ 1500.00

ChemScene
ASP5878 99.71%
50mg
$ 2100.00

Total 6 raw suppliers

Chemical Property of 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethanol

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

ASP5878 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses ASP5878 is a selective inhibitor of FGFR1, 2, 3 and 4.

Technology Process of 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethanol

There total 6 articles about 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 948571-47-9
2-(4-amino-1H-pyrazol-1-yl)ethan-1-ol

: 1453211-61-4
2-chloro-5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidine

: 1453208-66-6
2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethanol

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 20 - 100 ℃; for 6h; Inert atmosphere;

Reference yield:

: 1208434-90-5
(2,6-difluoro-3,5-dimethoxyphenyl)methanol

: 1453208-66-6
2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

3: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate; palladium diacetate / 1,4-dioxane / 6 h / 20 - 100 °C / Inert atmosphere

With palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1453211-60-3
(2,6-difluoro-3,5-dimethoxyphenyl)methyl methanesulfonate

: 1453208-66-6
2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate; palladium diacetate / 1,4-dioxane / 6 h / 20 - 100 °C / Inert atmosphere

With palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; N,N-dimethyl-formamide;