tert-butyl 4-{2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl}piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-{2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl}piperazine-1-carboxylate
• CAS No.: 1453212-89-9
• Molecular Formula: C₂₇H₃₅F₂N₇O₅
• Molecular Weight: 575.616
• Mol file: 1453212-89-9.mol

Synonyms:tert-butyl 4-{2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl}piperazine-1-carboxylate

Chemical Property of tert-butyl 4-{2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl}piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-{2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl}piperazine-1-carboxylate

There total 6 articles about tert-butyl 4-{2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl}piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl methanesulfonate (1453212-32-2) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-{2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl}piperazine-1-carboxylate (1453212-89-9)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 80 - 120 ℃;

Reference yield:

(2,6-difluoro-3,5-dimethoxyphenyl)methyl methanesulfonate (1453211-60-3) → tert-butyl 4-{2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl}piperazine-1-carboxylate (1453212-89-9)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; caesium carbonate / 1,4-dioxane / 30 h / 100 °C / Inert atmosphere

3: triethylamine / tetrahydrofuran / 4 h / 0 °C

4: 1-methyl-pyrrolidin-2-one / 80 - 120 °C

With palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; 2: |Buchwald-Hartwig Coupling;

DOI:10.1016/j.bmc.2022.116657

Reference yield:

2-chloro-5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidine (1453211-61-4) → tert-butyl 4-{2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl}piperazine-1-carboxylate (1453212-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; caesium carbonate / 1,4-dioxane / 30 h / 100 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 4 h / 0 °C

3: 1-methyl-pyrrolidin-2-one / 80 - 120 °C

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; 1: |Buchwald-Hartwig Coupling;

DOI:10.1016/j.bmc.2022.116657

upstream raw materials:

2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]ethyl methanesulfonate

1-t-Butoxycarbonylpiperazine

(2,6-difluoro-3,5-dimethoxyphenyl)methanol

(2,6-difluoro-3,5-dimethoxyphenyl)methyl methanesulfonate