methyl 4-[1-(tert-butoxycarbonyl)-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Base Information

• Chemical Name: methyl 4-[1-(tert-butoxycarbonyl)-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate
• CAS No.: 1138432-15-1
• Molecular Formula: C₁₈H₃₀FNO₅
• Molecular Weight: 359.438

Synonyms:methyl 4-[1-(tert-butoxycarbonyl)-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Chemical Property of methyl 4-[1-(tert-butoxycarbonyl)-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Chemical Property:

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Technology Process of methyl 4-[1-(tert-butoxycarbonyl)-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

There total 2 articles about methyl 4-[1-(tert-butoxycarbonyl)-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl 4-[1-(tert-butoxycarbonyl)-(4S)-fluoro-(2S)-pyrrolidinyl]methoxybenzoate (317356-28-8) → methyl 4-[1-(tert-butoxycarbonyl)-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate (1138432-15-1)

Guidance literature:

With 5% Rh/Al2O3; hydrogen; acetic acid; In ethanol; at 20 ℃; for 24h; under 7600.51 Torr;

DOI:10.1016/j.bmc.2008.12.026

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + methyl 4-[(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate (441769-11-5) → methyl 4-[1-(tert-butoxycarbonyl)-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate (1138432-15-1)

Guidance literature:

With triethylamine; In water; acetonitrile;

DOI:10.1021/jm901154c

Reference yield: 84.0%

methyl 4-[1-(tert-butoxycarbonyl)-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate (1138432-15-1) → methyl 4-[(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate (441769-11-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/j.bmc.2008.12.026

upstream raw materials:

methyl 4-[1-(tert-butoxycarbonyl)-(4S)-fluoro-(2S)-pyrrolidinyl]methoxybenzoate

di-tert-butyl dicarbonate

methyl 4-[(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Downstream raw materials:

methyl 4-[(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

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