4-(4-benzylpiperazin-1-yl)-2-oxo-5,6-dihydro-2H-benzo[h]chromene-3-carbonitrile

Base Information

• Chemical Name: 4-(4-benzylpiperazin-1-yl)-2-oxo-5,6-dihydro-2H-benzo[h]chromene-3-carbonitrile
• CAS No.: 933463-36-6
• Molecular Formula: C₂₅H₂₃N₃O₂
• Molecular Weight: 397.477
• Mol file: 933463-36-6.mol

Synonyms:4-(4-benzylpiperazin-1-yl)-2-oxo-5,6-dihydro-2H-benzo[h]chromene-3-carbonitrile

Chemical Property of 4-(4-benzylpiperazin-1-yl)-2-oxo-5,6-dihydro-2H-benzo[h]chromene-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-benzylpiperazin-1-yl)-2-oxo-5,6-dihydro-2H-benzo[h]chromene-3-carbonitrile

There total 2 articles about 4-(4-benzylpiperazin-1-yl)-2-oxo-5,6-dihydro-2H-benzo[h]chromene-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-oxo-4-methylsulfanyl-5,6-dihydro-2H-benzo[h]chromene-3-carbonitrile (299440-32-7) + 1-phenylmethylpiperazine (2759-28-6) → 4-(4-benzylpiperazin-1-yl)-2-oxo-5,6-dihydro-2H-benzo[h]chromene-3-carbonitrile (933463-36-6)

Guidance literature:

In ethanol; Heating;

DOI:10.1016/j.tetlet.2007.11.014

Reference yield: 79.0%

1-phenylmethylpiperazine (2759-28-6) + ethyl 2-cyano-3,3-di(methylsulfanyl)acrylate (17823-58-4) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 4-(4-benzylpiperazin-1-yl)-2-oxo-5,6-dihydro-2H-benzo[h]chromene-3-carbonitrile (933463-36-6)

Guidance literature:

ethyl 2-cyano-3,3-di(methylsulfanyl)acrylate; 3,4-dihydronaphthalene-1(2H)-one; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 24h;

1-phenylmethylpiperazine; In ethanol; Reflux;

DOI:10.1039/d1ob00314c

Reference yield: 95.0%

4-(4-benzylpiperazin-1-yl)-2-oxo-5,6-dihydro-2H-benzo[h]chromene-3-carbonitrile (933463-36-6) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 6-(4-benzylpiperazin-1-yl)-1,2,3,4,7,8-hexahydrobenzo[c]phenanthrene-5-carbonitrile (1215222-45-9)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tet.2009.12.026

upstream raw materials:

2-oxo-4-methylsulfanyl-5,6-dihydro-2H-benzo[h]chromene-3-carbonitrile

1-phenylmethylpiperazine

ethyl 2-cyano-3,3-di(methylsulfanyl)acrylate

3,4-dihydronaphthalene-1(2H)-one

Downstream raw materials:

C₃₄H₃₉N₃

C₂₉H₂₉N₃O

C₂₉H₂₉N₃S

C₂₉H₂₉N₃