2-(4-((3-nitro-6-(1H-indazol-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-((3-nitro-6-(1H-indazol-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile
CAS No.:1201645-18-2
Molecular Formula:C₂₇H₂₁N₅O₂
Molecular Weight:447.496
Hs Code.:

Synonyms:2-(4-((3-nitro-6-(1H-indazol-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

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Chemical Property of 2-(4-((3-nitro-6-(1H-indazol-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

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Technology Process of 2-(4-((3-nitro-6-(1H-indazol-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

There total 12 articles about 2-(4-((3-nitro-6-(1H-indazol-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1201645-07-9
2-methyl-2-(4-((3-nitro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-4-yl)methyl)phenyl)propanenitrile

: 66607-27-0
3-iodoindazole

: 1201645-18-2
2-(4-((3-nitro-6-(1H-indazol-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1201645-18-2
2-(4-((3-nitro-6-(1H-indazol-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

2.2: 25 °C

3.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

4.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

5.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

6.1: hydrogenchloride / acetone / 24 h

7.1: hydrogenchloride / water / 24 h

8.1: potassium acetate / ethanol / 5 h / Reflux

9.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene / 8 h / Inert atmosphere; Reflux

10.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 0.5 h / 100 °C / Microwave irradiation

With hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; potassium acetate; sodium hydride; sodium carbonate; caesium carbonate; ozone; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene; 10.1: Suzuki Coupling;

Reference yield:

: 4-(1-cyano-1-methylethyl)benzoic acid chloride

: 1201645-18-2
2-(4-((3-nitro-6-(1H-indazol-3-yl)quinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

1.2: 25 °C

2.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

5.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

6.1: hydrogenchloride / acetone / 24 h

7.1: hydrogenchloride / water / 24 h

8.1: potassium acetate / ethanol / 5 h / Reflux

9.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene / 8 h / Inert atmosphere; Reflux

10.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 0.5 h / 100 °C / Microwave irradiation

With hydrogenchloride; triethylsilane; aluminum (III) chloride; sodium tetrahydroborate; potassium acetate; sodium carbonate; caesium carbonate; ozone; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; 10.1: Suzuki Coupling;