Technology Process of 2-methyl-2-(4-((3-nitro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-4-yl)methyl)phenyl)propanenitrile
There total 12 articles about 2-methyl-2-(4-((3-nitro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-4-yl)methyl)phenyl)propanenitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium acetate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
toluene;
for 8h;
Inert atmosphere;
Reflux;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C
2.2: 25 °C
3.1: sodium tetrahydroborate / methanol / 2 h / 20 °C
4.1: triethylsilane; trifluoroacetic acid / dichloromethane / 2 h / 20 °C
5.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C
6.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C
7.1: hydrogenchloride / acetone / 24 h
8.1: hydrogenchloride / water / 24 h
9.1: potassium acetate / ethanol / 5 h / Reflux
10.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene / 8 h / Inert atmosphere; Reflux
With
hydrogenchloride; triethylsilane; aluminum (III) chloride; sodium tetrahydroborate; potassium acetate; sodium hydride; caesium carbonate; ozone; trifluoroacetic acid;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C
1.2: 25 °C
2.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere
3.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C
4.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C
5.1: hydrogenchloride / acetone / 24 h
6.1: hydrogenchloride / water / 24 h
7.1: potassium acetate / ethanol / 5 h / Reflux
8.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene / 8 h / Inert atmosphere; Reflux
With
hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; potassium acetate; caesium carbonate; ozone; trifluoroacetic acid;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;
