N-4-benzoyl-1-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]cytosine

Base Information

Chemical Name:N-4-benzoyl-1-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]cytosine
CAS No.:705254-36-0
Molecular Formula:C₂₉H₂₉N₃O₅
Molecular Weight:499.566
Hs Code.:

Synonyms:N-4-benzoyl-1-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]cytosine

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Chemical Property of N-4-benzoyl-1-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]cytosine

Chemical Property:

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Technology Process of N-4-benzoyl-1-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]cytosine

There total 1 articles about N-4-benzoyl-1-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 26661-13-2
4-N-benzoylcytosine

: 27441-81-2
2,2-bis((benzyloxy)methyl)oxirane

: 705254-36-0
N-4-benzoyl-1-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]cytosine

Guidance literature:: 4-N-benzoylcytosine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

2,2-bis((benzyloxy)methyl)oxirane; In N,N-dimethyl-formamide; at 110 ℃; for 24h; Further stages.;
DOI:10.1039/b316304k

Reference yield:

: 705254-36-0
N-4-benzoyl-1-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]cytosine

: 705254-44-0
1-[3-dimethyoxytrityloxy-2-(dimethoxytrityloxymethyl)prop-1-enyl]cytosine

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 0.75 h / 20 °C

2.1: 4.05 g / S₈ / 1.5 h

3.1: 52 percent / t-amyl alcohol; NaH / toluene / 4 h / 20 °C

4.1: BCl₃ / CH₂Cl₂ / 1 h / 0 °C

4.2: 0.120 g / pyridine / 1.5 h / 20 °C

5.1: aq. NH₃ / CH₂Cl₂; propan-2-ol / 20 °C

With pyridine; sulfur; ammonium hydroxide; tert-Amyl alcohol; boron trichloride; sodium hydride; In dichloromethane; isopropyl alcohol; toluene;
DOI:10.1039/b316304k

Reference yield:

: 705254-36-0
N-4-benzoyl-1-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]cytosine

: 705254-43-9
N-4-benzoyl-1-[3-dimethyoxytrityloxy-2-(dimethoxytrityloxymethyl)prop-1-enyl]cytosine

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 0.75 h / 20 °C

2.1: 4.05 g / S₈ / 1.5 h

3.1: 52 percent / t-amyl alcohol; NaH / toluene / 4 h / 20 °C

4.1: BCl₃ / CH₂Cl₂ / 1 h / 0 °C

4.2: 0.120 g / pyridine / 1.5 h / 20 °C

With pyridine; sulfur; tert-Amyl alcohol; boron trichloride; sodium hydride; In dichloromethane; toluene;
DOI:10.1039/b316304k