27441-81-2Relevant academic research and scientific papers
Synthesis of Functionalized 1,4-Dioxanes with an Additional (Hetero)Aliphatic Ring
Bondarenko, Andriy V.,Tolmachev, Andrey A.,Vashchenko, Bohdan V.,Grygorenko, Oleksandr O.
, p. 3696 - 3707 (2018/09/14)
An approach to the preparation of 2-mono-, 2,2- and 2,3-disubstituted 1,4-dioxane derivatives is described. The reaction sequence commences from readily available epoxides, in most cases prepared via the Corey-Chaikovsky reaction of the corresponding aldehydes and ketones. The key step of the method is epoxide ring opening with ethylene glycol monosodium salt, followed by further cyclization of the diols obtained. The utility of the approach was demonstrated by multigram preparation of novel functionalized 1,4-dioxanes bearing additional cycloalkane, piperidine or pyrrolidine rings, mostly spirocyclic compounds, which are advanced building blocks for medicinal chemistry.
TRICYCLIC BORON COMPOUNDS FOR ANTIMICROBIAL THERAPY
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Paragraph 0121; 0123; 0141; 0142, (2013/07/05)
Provided herein are antimicrobial tricyclic boron compounds of the following formula I: or pharmaceutically acceptable salts, complexes, or tautomers thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use
Synthesis and evaluation of a new class of tertiary alcohol based BACE-1 inhibitors
Russo, Francesco,W?ngsell, Fredrik,S?vmarker, Jonas,Jacobsson, Micael,Larhed, Mats
experimental part, p. 10047 - 10059 (2010/02/28)
BACE-1 has emerged as one of the best characterized targets for future Alzheimer therapy. In accordance with the successful identification of masked inhibitors of HIV-1 protease, we envisioned that tert-alcohol containing transition-state mimicking struct
The first example of a new type of acyclic, achiral nucleoside analogue: 1-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]thymine
Pedersen,Boesen,Eldrup,Kiaer,Madsen,Henriksen,Dahl
, p. 1656 - 1661 (2007/10/03)
Various preparative routes to 1-(dihydroxyalk-1-enyl)thymines, which are acyclic, achiral nucleoside analogues, have been examined, and a successful synthesis of 1-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]thymine (1, B = T) has been devised.
