RK-33

Base Information

Chemical Name:RK-33
CAS No.:1070773-09-9
Molecular Formula:C₂₃H₂₀N₆O₃
Molecular Weight:428.45
Hs Code.:
Mol file:1070773-09-9.mol

Synonyms:RK-33

Suppliers and Price of RK-33

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
RK33
5mg
$ 140.00

DC Chemicals
RK-33 >98%
100 mg
$ 400.00

ApexBio Technology
RK-33
5mg
$ 124.00

American Custom Chemicals Corporation
[1,3]DIAZEPIN-2-ONE, 3,7-DIHYDRO-3,7-BIS[(4-METHOXYPHENYL)METHYL]-2H-DIIMIDAZO 95.00%
5MG
$ 505.62

Ambeed
RK-33 98+%
50mg
$ 940.00

Ambeed
RK-33 98+%
25mg
$ 495.00

Ambeed
RK-33 98+%
10mg
$ 235.00

Ambeed
RK-33 98+%
5mg
$ 139.00

Ambeed
RK-33 98+%
2mg
$ 76.00

Ambeed
RK-33 98+%
1mg
$ 45.00

Total 13 raw suppliers

Chemical Property of RK-33

Chemical Property:

Melting Point:175-177 °C
Boiling Point:677.0±65.0 °C(Predicted)
PKA:3.40±0.20(Predicted)
Density:1.38±0.1 g/cm3(Predicted)
Storage Temp.:2-8°C
Solubility.:Soluble in DMSO (up to 20 mg/ml).

Purity/Quality:

99%, ^*data from raw suppliers

RK33 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description RK-33 (1070773-09-9) is an inhibitor of the RNA helicase DDX3 – IC50’s = 4.4-8.4 μM in high DDX3 expressing lung cancer cell lines A549, H1299, H23, and H460.1,2?Inhibition of DDX3 led to activation of cell death pathways, inhibition of Wnt pathway signaling, and abrogation of non-homologous end-joining (NHEJ) DNA repair. RK-33 was also active in colorectal cancer?3, prostate cancer4, and medulloblastoma cancer5?cell lines. RK-33 caused radiosensitization in breast cancer through inhibition of mitochondrial translation.6?RK-33 facilitates differentiation in human embryonic stem cells (hESC) and decreases pluripotency markers as well as reducing teratoma formation.7
Uses RK 33 is an inhibitor of DDX3, an ATP-dependent RNA helicase (1). Aberrant regulation of DDX3 is related to various diseases such as prostate and breast cancer (2). RK 33 was shown to decrease proliferation of prostate cancer cells and induced a G1 phase cell-cycle arrest (2).

Technology Process of RK-33

There total 1 articles about RK-33 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%