(2S)-2-(4-fluorophenyl)-2-trimethylsilyloxyacetonitrile

Base Information

Chemical Name:(2S)-2-(4-fluorophenyl)-2-trimethylsilyloxyacetonitrile
CAS No.:214630-15-6
Molecular Formula:C₁₁H₁₄FNOSi
Molecular Weight:223.322
Hs Code.:
DSSTox Substance ID:DTXSID601202235
Nikkaji Number:J1.003.626G

Synonyms:214630-15-6;DTXSID601202235;(alphaS)-4-Fluoro-alpha-[(trimethylsilyl)oxy]benzeneacetonitrile

Suppliers and Price of (2S)-2-(4-fluorophenyl)-2-trimethylsilyloxyacetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-2-(4-fluorophenyl)-2-trimethylsilyloxyacetonitrile

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:223.08286877
Heavy Atom Count:15
Complexity:247

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C[Si](C)(C)OC(C#N)C1=CC=C(C=C1)F
Isomeric SMILES:C[Si](C)(C)O[C@H](C#N)C1=CC=C(C=C1)F

Technology Process of (2S)-2-(4-fluorophenyl)-2-trimethylsilyloxyacetonitrile

There total 2 articles about (2S)-2-(4-fluorophenyl)-2-trimethylsilyloxyacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 7677-24-9
trimethylsilyl cyanide

: 459-57-4
4-fluorobenzaldehyde

: 214630-15-6
(S)-2-(4-fluorophenyl)-2-(trimethylsilyloxy)acetonitrile

Guidance literature:: With C₇₃H₉₄N₄O₁₀Ti₂*3H₂O; In dichloromethane; at 0 ℃; for 5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201002127

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 459-57-4
4-fluorobenzaldehyde

: 214630-15-6
(S)-2-(4-fluorophenyl)-2-(trimethylsilyloxy)acetonitrile

: (2R)-trimethylsilyloxy(4-fluorophenyl)acetonitrile

Guidance literature:: With Y₅(OiPr)13O; (R,R)-1,3-bis(2-methylferrocenyl)propane-1,3-dione; In dichloromethane; at -78 ℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo960271l