2-{2-[(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}-2-oxoethyl acetate

Base Information

Chemical Name:2-{2-[(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}-2-oxoethyl acetate
CAS No.:960492-76-6
Molecular Formula:C₁₈H₁₈BrN₅O₅
Molecular Weight:464.275
Hs Code.:

Synonyms:2-{2-[(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}-2-oxoethyl acetate

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Chemical Property of 2-{2-[(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}-2-oxoethyl acetate

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Technology Process of 2-{2-[(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}-2-oxoethyl acetate

There total 8 articles about 2-{2-[(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}-2-oxoethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 960492-75-5
6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazine-3-carbohydrazide

: 13831-31-7
Acetoxyacetyl chloride

: 960492-76-6
2-{2-[(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}-2-oxoethyl acetate

Guidance literature:: In dichloromethane; water; for 2h;
DOI:10.1016/j.bmcl.2010.10.107

Reference yield:

: 1121-79-5
3-chloro-6-methylpyridazine

: 960492-76-6
2-{2-[(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium dichromate; sulfuric acid / 3.33 h / 60 - 65 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

3: dichloromethane / 1 h / 0 - 10 °C

4: potassium carbonate / 1,4-dioxane / 16 h / Heating / reflux

5: hydrazine / ethanol / 6 h / 20 °C

6: dichloromethane; water / 1 h / 0 - 20 °C

With potassium dichromate; oxalyl dichloride; sulfuric acid; potassium carbonate; hydrazine; N,N-dimethyl-formamide; In 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 5096-73-1
6-chloro-pyridazine-3-carboxylic acid

: 960492-76-6
2-{2-[(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

2: dichloromethane / 1 h / 0 - 10 °C

3: potassium carbonate / 1,4-dioxane / 16 h / Heating / reflux

4: hydrazine / ethanol / 6 h / 20 °C

5: dichloromethane; water / 1 h / 0 - 20 °C

With oxalyl dichloride; potassium carbonate; hydrazine; N,N-dimethyl-formamide; In 1,4-dioxane; ethanol; dichloromethane; water;