[5-(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)-1,3,4-oxadiazol-2-yl]methyl acetate

Base Information

Chemical Name:[5-(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)-1,3,4-oxadiazol-2-yl]methyl acetate
CAS No.:960492-77-7
Molecular Formula:C₁₈H₁₆BrN₅O₄
Molecular Weight:446.26
Hs Code.:

Synonyms:[5-(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)-1,3,4-oxadiazol-2-yl]methyl acetate

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Chemical Property of [5-(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)-1,3,4-oxadiazol-2-yl]methyl acetate

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Technology Process of [5-(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)-1,3,4-oxadiazol-2-yl]methyl acetate

There total 9 articles about [5-(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)-1,3,4-oxadiazol-2-yl]methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 960492-76-6
2-{2-[(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}-2-oxoethyl acetate

: 960492-77-7
[5-(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)-1,3,4-oxadiazol-2-yl]methyl acetate

Guidance literature:: With Burgess Reagent; In tetrahydrofuran; at 150 ℃; for 0.5h; Microwave irradiation;
DOI:10.1016/j.bmcl.2010.10.107

Reference yield:

: 1121-79-5
3-chloro-6-methylpyridazine

: 960492-77-7
[5-(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)-1,3,4-oxadiazol-2-yl]methyl acetate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium dichromate; sulfuric acid / 3.33 h / 60 - 65 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

3: dichloromethane / 1 h / 0 - 10 °C

4: potassium carbonate / 1,4-dioxane / 16 h / Heating / reflux

5: hydrazine / ethanol / 6 h / 20 °C

6: dichloromethane; water / 1 h / 0 - 20 °C

7: Burgess Reagent / tetrahydrofuran / 0.5 h / 150 °C / microwave irradiation

With potassium dichromate; oxalyl dichloride; Burgess Reagent; sulfuric acid; potassium carbonate; hydrazine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 5096-73-1
6-chloro-pyridazine-3-carboxylic acid

: 960492-77-7
[5-(6-{3-[(2-bromophenyl)oxy]azetidin-1-yl}pyridazin-3-yl)-1,3,4-oxadiazol-2-yl]methyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

2: dichloromethane / 1 h / 0 - 10 °C

3: potassium carbonate / 1,4-dioxane / 16 h / Heating / reflux

4: hydrazine / ethanol / 6 h / 20 °C

5: dichloromethane; water / 1 h / 0 - 20 °C

6: Burgess Reagent / tetrahydrofuran / 0.5 h / 150 °C / microwave irradiation

With oxalyl dichloride; Burgess Reagent; potassium carbonate; hydrazine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;