(R)-2-methylpropane-2-sulfinic acid (2R,3S)-[2-phenyl-1-(toluene-4-sulfonyl)piperidin-3-yl]-amide

Base Information

• Chemical Name: (R)-2-methylpropane-2-sulfinic acid (2R,3S)-[2-phenyl-1-(toluene-4-sulfonyl)piperidin-3-yl]-amide
• CAS No.: 942263-58-3
• Molecular Formula: C₂₂H₃₀N₂O₃S₂
• Molecular Weight: 434.624

Synonyms:(R)-2-methylpropane-2-sulfinic acid (2R,3S)-[2-phenyl-1-(toluene-4-sulfonyl)piperidin-3-yl]-amide

Chemical Property of (R)-2-methylpropane-2-sulfinic acid (2R,3S)-[2-phenyl-1-(toluene-4-sulfonyl)piperidin-3-yl]-amide

Chemical Property:

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Technology Process of (R)-2-methylpropane-2-sulfinic acid (2R,3S)-[2-phenyl-1-(toluene-4-sulfonyl)piperidin-3-yl]-amide

There total 2 articles about (R)-2-methylpropane-2-sulfinic acid (2R,3S)-[2-phenyl-1-(toluene-4-sulfonyl)piperidin-3-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-methyl-N-{3-[(2S,3S)-3-phenyl-1-((R)-2-methylpropane-2-sulfinyl)-aziridin-2-yl]propyl}-benzenesulfonamide (942263-55-0) → (R)-2-methylpropane-2-sulfinic acid (2R,3S)-[2-phenyl-1-(toluene-4-sulfonyl)piperidin-3-yl]-amide (942263-58-3)

Guidance literature:

With ytterbium(III) triflate; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1021/ol070507f

Reference yield:

4-methyl-N-{3-[3-phenyl-1-((R)-2-methylpropane-2-sulfinyl)-aziridin-2-yl]propyl}-benzenesulfonamide → (R)-2-methylpropane-2-sulfinic acid {(S)-phenyl-[(R)-1-(toluene-4-sulfonyl)pyrrolidin-2-yl]-methyl}amide + (R)-2-methylpropane-2-sulfinic acid (2R,3S)-[2-phenyl-1-(toluene-4-sulfonyl)piperidin-3-yl]-amide (942263-58-3)

Guidance literature:

In tetrahydrofuran; for 15h; Heating;

DOI:10.1021/ol070507f

Reference yield: 88.0%

(R)-2-methylpropane-2-sulfinic acid (2R,3S)-[2-phenyl-1-(toluene-4-sulfonyl)piperidin-3-yl]-amide (942263-58-3) → (2R,3S)-2-phenyl-1-(toluene-4-sulfonyl)-piperidin-3-ylamide

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethanol;

DOI:10.1021/ol070507f

upstream raw materials:

4-methyl-N-{3-[(2S,3S)-3-phenyl-1-((R)-2-methylpropane-2-sulfinyl)-aziridin-2-yl]propyl}-benzenesulfonamide

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