2-[2-[2-[2-tert-butoxycarbonylamino-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid benzyl ester

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Chemical Name:2-[2-[2-[2-tert-butoxycarbonylamino-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid benzyl ester
CAS No.:376648-86-1
Molecular Formula:C₄₀H₅₂F₁₂N₈O₁₁
Molecular Weight:1048.88
Hs Code.:

2-[2-[2-[2-<i>tert</i>-butoxycarbonylamino-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid benzyl ester

Synonyms:2-[2-[2-[2-tert-butoxycarbonylamino-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid benzyl ester

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Chemical Property of 2-[2-[2-[2-tert-butoxycarbonylamino-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid benzyl ester

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Technology Process of 2-[2-[2-[2-tert-butoxycarbonylamino-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid benzyl ester

There total 7 articles about 2-[2-[2-[2-tert-butoxycarbonylamino-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 376648-85-0
(S)-2-[(S)-2-tert-Butoxycarbonylamino-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid

: (S)-2-[(S)-2-Amino-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid benzyl ester; hydrochloride

: 376648-86-1
2-[2-[2-[2-tert-butoxycarbonylamino-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid benzyl ester

Guidance literature:: (S)-2-[(S)-2-Amino-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid benzyl ester; hydrochloride; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide; at -40 ℃; for 1h;

(S)-2-[(S)-2-tert-Butoxycarbonylamino-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid; With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; at -40 - 20 ℃; Further stages.;
DOI:10.1021/ol0161108

Reference yield:

: 63865-89-4
(2S)-2-[(tert-butoxycarbonyl)amino]-5-(2,2,2-trifluoroacetamido)pentanoic acid

: 376648-86-1
2-[2-[2-[2-tert-butoxycarbonylamino-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran; dimethylformamide / 1 h / -40 °C

1.2: 97 percent / N-methylmorpholine / tetrahydrofuran; dimethylformamide / -40 - 20 °C

2.1: 100 percent / H₂ / Pd/C / methanol / 12 h / 20 °C / 760.05 Torr

3.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran; dimethylformamide / 1 h / -40 °C

3.2: 97 percent / N-methylmorpholine / tetrahydrofuran; dimethylformamide / -40 - 20 °C

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ol0161108

Reference yield:

: 2480-93-5
Boc-Orn(Z)-OH

: 376648-86-1
2-[2-[2-[2-tert-butoxycarbonylamino-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoylamino]-5-(2,2,2-trifluoro-acetylamino)-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / Pd/C / methanol / 12 h / 20 °C / 760.05 Torr

2.1: Et₃N / methanol / 9 h

3.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran; dimethylformamide / 1 h / -40 °C

3.2: 97 percent / N-methylmorpholine / tetrahydrofuran; dimethylformamide / -40 - 20 °C

4.1: 100 percent / H₂ / Pd/C / methanol / 12 h / 20 °C / 760.05 Torr

5.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran; dimethylformamide / 1 h / -40 °C

5.2: 97 percent / N-methylmorpholine / tetrahydrofuran; dimethylformamide / -40 - 20 °C

With 4-methyl-morpholine; hydrogen; triethylamine; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ol0161108