α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride

Base Information

Chemical Name:α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride
CAS No.:110038-98-7
Molecular Formula:C₃₁H₃₂ClNO₄*ClH
Molecular Weight:554.513
Hs Code.:

Synonyms:α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride

Suppliers and Price of α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride

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Technology Process of α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride

There total 12 articles about α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 110038-95-4
2-Chloro-N-<2-hydroxy-2-<4-(phenylmethoxy)phenyl>ethyl>-4-methoxy-3-(phenylmethoxy)benzeneacetamide

: 110038-98-7
α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride

Guidance literature:: With hydrogenchloride; methanol; borane; 1.) THF, reflux, 1.5 h, 2.) reflux, 2 h, 3.) ether;;
DOI:10.1002/jhet.5570230641

Reference yield:

: 621-59-0
isovanillin

: 110038-98-7
α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: 71 percent / Cl₂ / CH₂Cl₂ / 1.) -20 to -25 deg C, 6 h, 2.) room temperature, overnight;

2: 83 percent / K₂CO₃ / dimethylformamide / 36 h / Ambient temperature

3: 67 percent / NaBH₄ / propan-2-ol / 1 h / 70 °C

4: 92 percent / SOCl₂ / CH₂Cl₂ / 1.5 h / Heating

5: 57 percent / dimethylsulfoxide / 3 h / Ambient temperature

6: 79 percent / aq. 25percent NaOH / ethanol / Heating; overnight

7: SOCl₂ / CH₂Cl₂ / 2.5 h / Heating

8: K₂CO₃ / H₂O; toluene; CH₂Cl₂ / 1 h

9: 82 percent / 1.) borane, 2.) methanol, 3.) HCl gas; / 1.) THF, reflux, 1.5 h, 2.) reflux, 2 h, 3.) ether;

With hydrogenchloride; methanol; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; borane; chlorine; potassium carbonate; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1002/jhet.5570230641

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 110038-98-7
α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / NH₄Cl / H₂O; diethyl ether / 24 h / Ambient temperature

2: 57 percent / 1.) borane, 2.) methanol, 3.) HCl gas / 1.) THF, reflux, 3.5 h, 2.) reflux 45 min, 3.) reflux, 15 h;

3: K₂CO₃ / H₂O; toluene; CH₂Cl₂ / 1 h

4: 82 percent / 1.) borane, 2.) methanol, 3.) HCl gas; / 1.) THF, reflux, 1.5 h, 2.) reflux, 2 h, 3.) ether;

With hydrogenchloride; methanol; borane; potassium carbonate; ammonium chloride; In diethyl ether; dichloromethane; water; toluene;
DOI:10.1002/jhet.5570230641