α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride

Base Information

• Chemical Name: α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride
• CAS No.: 110038-98-7
• Molecular Formula: C₃₁H₃₂ClNO₄*ClH
• Molecular Weight: 554.513
• Mol file: 110038-98-7.mol

Synonyms:α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride

Chemical Property of α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride

There total 12 articles about α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-Chloro-N-<2-hydroxy-2-<4-(phenylmethoxy)phenyl>ethyl>-4-methoxy-3-(phenylmethoxy)benzeneacetamide (110038-95-4) → α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride (110038-98-7)

Guidance literature:

With hydrogenchloride; methanol; borane; 1.) THF, reflux, 1.5 h, 2.) reflux, 2 h, 3.) ether;;

DOI:10.1002/jhet.5570230641

Reference yield:

isovanillin (621-59-0) → α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride (110038-98-7)

Guidance literature:

Multi-step reaction with 9 steps

1: 71 percent / Cl₂ / CH₂Cl₂ / 1.) -20 to -25 deg C, 6 h, 2.) room temperature, overnight;

2: 83 percent / K₂CO₃ / dimethylformamide / 36 h / Ambient temperature

3: 67 percent / NaBH₄ / propan-2-ol / 1 h / 70 °C

4: 92 percent / SOCl₂ / CH₂Cl₂ / 1.5 h / Heating

5: 57 percent / dimethylsulfoxide / 3 h / Ambient temperature

6: 79 percent / aq. 25percent NaOH / ethanol / Heating; overnight

7: SOCl₂ / CH₂Cl₂ / 2.5 h / Heating

8: K₂CO₃ / H₂O; toluene; CH₂Cl₂ / 1 h

9: 82 percent / 1.) borane, 2.) methanol, 3.) HCl gas; / 1.) THF, reflux, 1.5 h, 2.) reflux, 2 h, 3.) ether;

With hydrogenchloride; methanol; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; borane; chlorine; potassium carbonate; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

DOI:10.1002/jhet.5570230641

Reference yield:

p-benzyloxybenzaldehyde (4397-53-9) → α-<<<2-<2-Chloro-4-methoxy-3-(phenylmethoxy)phenyl>ethyl>amino>methyl>-4-(phenylmethoxy)benzenemethanol hydrochloride (110038-98-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / NH₄Cl / H₂O; diethyl ether / 24 h / Ambient temperature

2: 57 percent / 1.) borane, 2.) methanol, 3.) HCl gas / 1.) THF, reflux, 3.5 h, 2.) reflux 45 min, 3.) reflux, 15 h;

3: K₂CO₃ / H₂O; toluene; CH₂Cl₂ / 1 h

4: 82 percent / 1.) borane, 2.) methanol, 3.) HCl gas; / 1.) THF, reflux, 1.5 h, 2.) reflux, 2 h, 3.) ether;

With hydrogenchloride; methanol; borane; potassium carbonate; ammonium chloride; In diethyl ether; dichloromethane; water; toluene;

DOI:10.1002/jhet.5570230641

upstream raw materials:

2-Chloro-N-<2-hydroxy-2-<4-(phenylmethoxy)phenyl>ethyl>-4-methoxy-3-(phenylmethoxy)benzeneacetamide

isovanillin

p-benzyloxybenzaldehyde

3-benzyloxy-2-chloro-4-methoxy-benzaldehyde

Downstream raw materials:

α-<<<2-(2-Chloro-3-hydroxy-4-methoxyphenyl)ethyl>amino>methyl>-4-hydroxybenzenemethanol hydrochloride

6-Chloro-2,3,4,5-tetrahydro-7-hydroxy-1-(4-hydroxyphenyl)-8-methoxy-1H-3-benzazepine hydrochloride

Refernces