tert-butyl 3-(4-nitrobenzyl)-6,6a-dihydro-3aH-pyrrolo[3,4-d]isoxazole-5(4H)-carboxylate

Base Information

Chemical Name:tert-butyl 3-(4-nitrobenzyl)-6,6a-dihydro-3aH-pyrrolo[3,4-d]isoxazole-5(4H)-carboxylate
CAS No.:1253183-40-2
Molecular Formula:C₁₇H₂₁N₃O₅
Molecular Weight:347.371
Hs Code.:

Synonyms:tert-butyl 3-(4-nitrobenzyl)-6,6a-dihydro-3aH-pyrrolo[3,4-d]isoxazole-5(4H)-carboxylate

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Chemical Property of tert-butyl 3-(4-nitrobenzyl)-6,6a-dihydro-3aH-pyrrolo[3,4-d]isoxazole-5(4H)-carboxylate

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Technology Process of tert-butyl 3-(4-nitrobenzyl)-6,6a-dihydro-3aH-pyrrolo[3,4-d]isoxazole-5(4H)-carboxylate

There total 3 articles about tert-butyl 3-(4-nitrobenzyl)-6,6a-dihydro-3aH-pyrrolo[3,4-d]isoxazole-5(4H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 163759-15-7
N-hydroxy-2-(4-nitrophenyl)acetimidoyl chloride

: 73286-70-1
N-(tert-butoxycarbonyl)-3-pyrroline

: 1253183-40-2
tert-butyl 3-(4-nitrobenzyl)-6,6a-dihydro-3aH-pyrrolo[3,4-d]isoxazole-5(4H)-carboxylate

Guidance literature:: With potassium carbonate; In ethyl acetate; at 90 ℃; for 0.166667h;
DOI:10.1021/jo1014323

Reference yield:

: 1460-05-5
p-nitrophenylacetaldehyde

: 1253183-40-2
tert-butyl 3-(4-nitrobenzyl)-6,6a-dihydro-3aH-pyrrolo[3,4-d]isoxazole-5(4H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium carbonate / methanol; water / 3 h / 20 °C

2: pyridine; N-chloro-succinimide / chloroform / 40 °C

3: potassium carbonate / ethyl acetate / 0.17 h / 90 °C / 5171.62 Torr / Inert atmosphere

With pyridine; N-chloro-succinimide; hydroxylamine hydrochloride; sodium carbonate; potassium carbonate; In methanol; chloroform; water; ethyl acetate;
DOI:10.1021/jm2010404

Reference yield:

: 1459-12-7
(p-nitrophenyl)acetaldehyde oxime

: 1253183-40-2
tert-butyl 3-(4-nitrobenzyl)-6,6a-dihydro-3aH-pyrrolo[3,4-d]isoxazole-5(4H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; N-chloro-succinimide / chloroform / 40 °C

2: potassium carbonate / ethyl acetate / 0.17 h / 90 °C / 5171.62 Torr / Inert atmosphere

With pyridine; N-chloro-succinimide; potassium carbonate; In chloroform; ethyl acetate;
DOI:10.1021/jm2010404