C₂₈H₂₂F₃N₃O₃

Base Information

Chemical Name:C₂₈H₂₂F₃N₃O₃
CAS No.:927426-45-7
Molecular Formula:C₂₈H₂₂F₃N₃O₃
Molecular Weight:505.496
Hs Code.:

C<sub>28</sub>H<sub>22</sub>F<sub>3</sub>N<sub>3</sub>O<sub>3</sub>

Synonyms:C₂₈H₂₂F₃N₃O₃

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Chemical Property of C₂₈H₂₂F₃N₃O₃

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Technology Process of C₂₈H₂₂F₃N₃O₃

There total 9 articles about C₂₈H₂₂F₃N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(2-amino-3-methoxy-propyl)-phenol

: 927426-45-7
C₂₈H₂₂F₃N₃O₃

Guidance literature:: C₁₈H₉F₃N₂O₂; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.166667h;

4-(2-amino-3-methoxy-propyl)-phenol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 927426-43-5
C₁₈H₉F₃N₂O₂

: 4-(2-amino-3-methoxy-propyl)-phenol

: 927426-45-7
C₂₈H₂₂F₃N₃O₃

Guidance literature:: C₁₈H₉F₃N₂O₂; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.166667h;

4-(2-amino-3-methoxy-propyl)-phenol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 540-37-4
p-aminoiodobenzene

: 927426-45-7
C₂₈H₂₂F₃N₃O₃

Guidance literature:: Multi-step reaction with 8 steps

1.1: methanol / 3 h / 20 °C

2.1: sodium hydroxide / methanol / 50 °C / Inert atmosphere

3.1: palladium diacetate / water / 2 h / 80 °C / Inert atmosphere

4.1: trichlorophosphate / 3 h / 20 °C / Reflux

5.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / dichloromethane / 12 h / 0 - 20 °C

6.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc(II) cyanide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide / 120 °C / Inert atmosphere

7.1: sodium hydroxide / water; methanol / Inert atmosphere

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.17 h / 20 °C

8.2: 20 °C

With zinc(II) cyanide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl acetamide; water;