N-(4-(benzyloxy)-3-(2-bromoacetyl)phenyl)-4-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-(4-(benzyloxy)-3-(2-bromoacetyl)phenyl)-4-(trifluoromethyl)benzamide
CAS No.:1429022-44-5
Molecular Formula:C₂₃H₁₇BrF₃NO₃
Molecular Weight:492.292
Hs Code.:

Synonyms:N-(4-(benzyloxy)-3-(2-bromoacetyl)phenyl)-4-(trifluoromethyl)benzamide

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Chemical Property of N-(4-(benzyloxy)-3-(2-bromoacetyl)phenyl)-4-(trifluoromethyl)benzamide

Chemical Property:

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Technology Process of N-(4-(benzyloxy)-3-(2-bromoacetyl)phenyl)-4-(trifluoromethyl)benzamide

There total 7 articles about N-(4-(benzyloxy)-3-(2-bromoacetyl)phenyl)-4-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1429022-35-4
N-(3-acetyl-4-(benzyloxy)phenyl)-4-trifluoromrthylbenzamide

: 1429022-44-5
N-(4-(benzyloxy)-3-(2-bromoacetyl)phenyl)-4-(trifluoromethyl)benzamide

Guidance literature:: With copper(ll) bromide; In ethanol; chloroform; for 2h; Reflux;
DOI:10.3390/molecules18033577

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 1429022-44-5
N-(4-(benzyloxy)-3-(2-bromoacetyl)phenyl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / 90 - 95 °C

2: aluminum (III) chloride / nitrobenzene / 6 h / 140 °C

3: potassium carbonate; potassium iodide; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile; water / 2 h / Reflux

4: tin(II) chloride dihdyrate / ethanol / 3 h / 45 °C

5: triethylamine / dichloromethane / 20 °C

6: copper(ll) bromide / ethanol; chloroform / 2 h / Reflux

With aluminum (III) chloride; tin(II) chloride dihdyrate; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; triethylamine; potassium iodide; sodium hydroxide; copper(ll) bromide; In ethanol; dichloromethane; chloroform; water; nitrobenzene; acetonitrile;
DOI:10.3390/molecules18033577

Reference yield:

: 830-03-5
4-nitrophenol acetate

: 1429022-44-5
N-(4-(benzyloxy)-3-(2-bromoacetyl)phenyl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: aluminum (III) chloride / nitrobenzene / 6 h / 140 °C

2: potassium carbonate; potassium iodide; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile; water / 2 h / Reflux

3: tin(II) chloride dihdyrate / ethanol / 3 h / 45 °C

4: triethylamine / dichloromethane / 20 °C

5: copper(ll) bromide / ethanol; chloroform / 2 h / Reflux

With aluminum (III) chloride; tin(II) chloride dihdyrate; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; triethylamine; potassium iodide; copper(ll) bromide; In ethanol; dichloromethane; chloroform; water; nitrobenzene; acetonitrile;
DOI:10.3390/molecules18033577