5-ethyl-3-[3-(trifluoromethyl)phenyl]-5-{[3-(trifluoromethyl)phenyl]carbamoyl}hydantoin

Base Information

Chemical Name:5-ethyl-3-[3-(trifluoromethyl)phenyl]-5-{[3-(trifluoromethyl)phenyl]carbamoyl}hydantoin
CAS No.:1395360-98-1
Molecular Formula:C₂₀H₁₅F₆N₃O₃
Molecular Weight:459.348
Hs Code.:

Synonyms:5-ethyl-3-[3-(trifluoromethyl)phenyl]-5-{[3-(trifluoromethyl)phenyl]carbamoyl}hydantoin

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Chemical Property of 5-ethyl-3-[3-(trifluoromethyl)phenyl]-5-{[3-(trifluoromethyl)phenyl]carbamoyl}hydantoin

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Technology Process of 5-ethyl-3-[3-(trifluoromethyl)phenyl]-5-{[3-(trifluoromethyl)phenyl]carbamoyl}hydantoin

There total 2 articles about 5-ethyl-3-[3-(trifluoromethyl)phenyl]-5-{[3-(trifluoromethyl)phenyl]carbamoyl}hydantoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1395360-84-5
2-(benzyloxycarbonylamino)-2-ethylmalonic acid

: 98-16-8
3-trifluoromethylaniline

: 1395361-17-7
2-ethyl-2-formamido-N₁,N₃-bis[3-(trifluoromethyl)phenyl]malonamide

: 1395360-98-1
5-ethyl-3-[3-(trifluoromethyl)phenyl]-5-{[3-(trifluoromethyl)phenyl]carbamoyl}hydantoin

Guidance literature:: 2-(benzyloxycarbonylamino)-2-ethylmalonic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; Inert atmosphere;

3-trifluoromethylaniline; With triethylamine; In 1,4-dioxane; at 20 ℃; for 24.5h; Inert atmosphere;
DOI:10.1055/s-0031-1290974

Reference yield:

: 1395360-80-1
diethyl 2-(benzyloxycarbonylamino)-2-ethylmalonate

: 1395361-17-7
2-ethyl-2-formamido-N₁,N₃-bis[3-(trifluoromethyl)phenyl]malonamide

: 1395360-98-1
5-ethyl-3-[3-(trifluoromethyl)phenyl]-5-{[3-(trifluoromethyl)phenyl]carbamoyl}hydantoin

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / ethanol / 96 h / 20 °C

1.2: Cooling with ice

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C / Inert atmosphere

2.2: 24.5 h / 20 °C / Inert atmosphere

With oxalyl dichloride; water; N,N-dimethyl-formamide; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1055/s-0031-1290974